Artículos de revistas
Antiproliferative Constituents Of Geopropolis From The Bee Melipona Scutellaris
Registro en:
1439-0221
Planta Medica. GEORG THIEME VERLAG KG, n. 82, n. 3, p. 190 - 194.
1439-0221
WOS:000369948100002
10.1055/s-0035-1558142
Autor
da Cunha
MG; Rosalen
PL; Franchin
M; de Alencar
SM; Ikegaki
M; Ransom
T; Beutler
JA
Institución
Resumen
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) Fractionation of geopropolis from Melipona scutellaris, guided by antiproliferative activity against two colon cancer cell lines (COLO205 and KM12), led to the isolation of two new cinnamic acid esters, mammea-type coumarins 5,7-dihydroxy-6(3-methyl-2-butenyl)-8-(4-cinnamoyl-3-methyl-1-oxobutyl)-4-propyl-coumarin (1) and 5,7-dihydroxy-6-(4-cinnamoyl-3-methyl-1-oxobutyl)-4-phenylcoumarin (2), along with five known coumarins, mammeigin (3), hydroxymammeigin (4), mammeisin (5), cinnamoyloxy-mammeisin (6), and mammein (7), and the prenylated benzophenone ent-nemorosone (8). Among the isolated compounds, 5 and 7 showed the highest cell growth inhibition against COLO205 (GI(50) 9.7 and 10.7 mu M, respectively) and KM12 (GI(50) 12.0 and 10.9 mu M, respectively). The presence of these compounds suggests that plants of Clusiaceae family, especially the genera Kielmeyera and Clusia, are likely to be major sources of geopropolis produced by M. scutellaris. 82
190 194 NIH, National Cancer Institute, Center for Cancer Research FAPESP [2011/23635-6, 2012/22002-2] Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)