Artículos de revistas
Preventive And Therapeutic Moderate Aerobic Exercise Programs Convert Atherosclerotic Plaques Into A More Stable Phenotype
Registro en:
1879-0631
Life Sciences. PERGAMON-ELSEVIER SCIENCE LTD, n. 153, p. 163 - 170.
1879-0631
WOS:000376484500019
10.1016/j.lfs.2016.04.007
Autor
Cardinot
TM; Lima
TM; Moretti
AIS; Koike
MK; Nunes
VS; Cazita
PM; Krieger
MH; Brum
PC; Souza
HP
Institución
Resumen
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) The mechanisms by which exercise affects atherosclerotic plaque stability remain incompletely understood. We evaluated the effects of two training protocols on both atherosclerotic plaque structure and the signaling pathways involved in plaque rupture. Methods: Male low-density lipoprotein (LDL) receptor knockout mice were fed a high-fat, high-cholesterol diet (HFD). One group was subjected to moderate exercise using a treadmill for 14 weeks (preventive protocol). The other group started an exercise regimen after 16 weeks of the HFD (therapeutic group). Atherosclerotic plaques within the aorta were evaluated for lipid and collagen contents, as well as for inflammatory markers. Plasma cholesterol and cytokine levels were also determined. Results: The mice receiving a HFD developed hypercholesterolemia and atherosclerotic plaques within the aorta. The aortas from the animals in the preventive protocol exhibited smaller lipid cores and higher collagen content. These animals also exhibited lower CD40 expression within the plaques. The aortas of the mice in the therapeutic group exhibited higher collagen content, but no differences in either lipid core size or plaque size were noted. No differences in blood pressure, plasma cholesterol, cytokine levels, plaque size or metalloproteinase 9 expression were observed in the trained animals compared with the sedentary animals. Conclusion: Moderate aerobic exercise modified atherosclerotic plaque characteristics and converted the plaques into a more stable phenotype, increasing the collagen content in response to both exercise programs. Furthermore, moderate aerobic exercise reduced the animals' fat content and decreased the activity of the CD40-CD40L signaling pathway in the preventive group. (C) 2016 Elsevier Inc. All rights reserved. 153
163 170 Fundacao de Amparo a Pesquisa do Estado de Sao Paulo [2009/01990-9] Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)