Artículos de revistas
Haplotypes of susceptibility to chronic periodontitis in the Interleukin 8 gene do not influence protein level in the gingival crevicular fluid
Registro en:
Archives of Oral Biology. Pergamon-Elsevier Science Ltd, v.57, n.10, p.1355-1361, 2012
0003-9969
WOS:000310409400008
10.1016/j.archoralbio.2012.07.003
Autor
Corbi, Samia C. T.
Anovazzi, Giovana
Finoti, Livia S.
Kim, Yeon J.
Capela, Marisa V.
Secolin, Rodrigo
Marcaccini, Andrea M.
Gerlach, Raquel F.
Orrico, Silvana R. P.
Cirelli, Joni A.
Scarel-Caminaga, Raquel M.
Institución
Resumen
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) Objective: Previously, we identified that the ATC/TTC haplotype formed by polymorphisms in the Interleukin-(IL)8 gene conferred susceptibility to chronic periodontitis (CP). The aim of the study was to investigate whether the IL8 haplotype ATC/TTC was associated with the volume of gingival crevicular fluid (GCF), the concentration of interleukin IL-8 in the GCF, as well as periodontal conditions in patients with CP in comparison to controls without CP. Methods: Seventy-nine individuals (CP: n = 41, controls: n = 38) were grouped according to the presence (susceptible for CP) or absence (not susceptible for CP) of the IL8 ATC/TTC haplotype. After periodontal clinical evaluation, they were subdivided by the presence or absence of CP. GCF was collected from each patient and the IL-8 levels were determined by ELISA. The GCF volume of each subject was measured by means of a calibrated electronic device. Comparisons of means between carriers and non-carriers of the ATC/TTC haplotype were evaluated using the Mann-Whitney test. Linear regression and stepwise linear regression analysis were used to analyse the association of the GCF volume with potential covariates and their contribution for the phenotype. Results: We did not find significant differences of both periodontal conditions and IL-8 concentration in the GCF of patients with the presence or absence of the IL8 ATC/TTC haplotype. However, the GCF volume was significantly higher amongst the patients affected by CP that are absent for the IL8 ATC/TTC haplotype. In addition, linear regression analysis showed a statistically significant association between GCF volume and CP, IL8 haplotype ATC/TTC and IL-8 concentration. Conclusions: The IL8 haplotype of susceptibility to CP was neither associated with IL-8 cytokine levels nor with clinical periodontal parameters. Also, CP, IL8 haplotype and IL-8 concentration showed a positive association with the GCF volume levels in the studied patients. (c) 2012 Published by Elsevier Ltd. 57 10 1355 1361 Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) The State of Sao Paulo Research Foundation (Fundacao de Amparo Pesquisa do Estado de Sao Paulo, FAPESP, Sao Paulo, SP) [2003/10424-0, 2009/08773-3] Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Ítems relacionados
Mostrando ítems relacionados por Título, autor o materia.
-
Avaliação do risco periodontal e aspectos oclusais de pacientes com periodontite grau C antes e após terapia periodontal não cirúrgica
Costa, Stefanny Danielle da Silva -
Periodontitis crónica y nivel de pérdida ósea periodontal en pacientes tratados por hipofunción tiroidea
Berríos, Marlyn; Peña Espinosa, José; Gutiérrez, Diana; García, Alida; Araque Diaz, Lilibeth