Artículos de revistas
Identification of a bioactive compound isolated from Brazilian propolis type 6
Registro en:
BIOORGANIC & MEDICINAL CHEMISTRY, v.17, n.14, p.5332-5335, 2009
0968-0896
10.1016/j.bmc.2009.04.066
Autor
CASTRO, Myrella Lessio
NASCIMENTO, Andrea Mendes do
IKEGAKI, Masaharu
COSTA-NETO, Claudio M.
ALENCAR, Severino M.
ROSALEN, Pedro L.
Institución
Resumen
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) A prenylated benzophenone, hyperibone A, was isolated from the hexane fraction of Brazilian propolis type 6. Its structure was determined by spectral analysis including 2D NMR. This compound exhibited cytotoxic activity against HeLa tumor cells (IC(50) = 0.1756 mu M), strong antimicrobial activity (MIC range-0.73-6.6 mu g/mL; MBC range-2.92-106 mu g/mL) against Streptococcus mutans, Streptococcus sobrinus, Streptococcus oralis, Staphylococcus aureus, and Actinomyces naeslundii, and the results of its cytotoxic and antimicrobial activities were considered good. (C) 2009 Elsevier Ltd. All rights reserved. 17 14 5332 5335 Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) FAPEMIG[EDT-240/05] Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)