Artículos de revistas
Analysis of phase transition and dehydration processes of nevirapine
Registro en:
Journal of Thermal Analysis and Calorimetry. Springer, v.108, n.1, p.53-57, 2012
1388-6150
WOS:000302704500007
10.1007/s10973-011-1424-x
Autor
de Oliveira, George G. G.
Ferraz, Humberto G.
Severino, Patricia
Souto, Eliana B.
Institución
Resumen
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) Solid-state characterization of crystalline drugs is an important pre-formulation step for the development and design of solid dosage forms, such as pellets and tablets. In this study, phase transition and dehydration processes of nevirapine have been studied by differential scanning calorimetry and thermogravimetry differential thermal analysis to overcome the problems of drug formulation, namely poor solubility and poor content uniformity. Phase solubility studies elucidated the mechanism of enhanced nevirapine solubility. 108 1 53 57 Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)