Artículos de revistas
Chemical constituents of the volatile oil from leaves of Annona coriacea and in vitro antiprotozoal activity
Registro en:
Revista Brasileira de Farmacognosia, v.21, n.1, 2011
0102-695X
10.1590/S0102-695X2011005000004
Autor
SIQUEIRA, Carlos A. T.
OLIANI, Jocimar
SARTORATTO, Adilson
QUEIROGA, Carmen L.
MORENO, Paulo R. H.
REIMÃO, Juliana Q.
TEMPONE, André G.
FISCHER, Dominique C. H.
Institución
Resumen
The essential oil of the leaves from Annona coriacea Mart., Annonaceae, was extracted by hydrodistillation in a Clevenger apparatus and analyzed by GC/MS and GC/FID. The oil yield was 0.05% m/m. Sixty compounds were identified, in a complex mixture of sesquiterpenes (76.7%), monoterpenes (20.0%) and other constituents (3.3%). Bicyclogermacrene was its major compound (39.8%) followed by other sesquiterpenes. Most of the monoterpenes were in low concentration (<1%). Only β-pinene and pseudolimonene presented the highest level of 1.6%. The volatile oil presented anti-leishmanial and trypanocidal activity against promastigotes of four species of Leishmania and trypomastigotes of Trypanosoma cruzi, showing to be more active against Leishmania (L.) chagasi (IC50 39.93 µ g/mL) (95% CI 28.00-56.95 µ g/mL). 21 1