Artículos de revistas
Melatonin Has An Ergogenic Effect But Does Not Prevent Inflammation And Damage In Exhaustive Exercise
Registro en:
Melatonin Has An Ergogenic Effect But Does Not Prevent Inflammation And Damage In Exhaustive Exercise. Nature Publishing Group, v. 5, p. DEC-2015.
2045-2322
WOS:000366478600001
10.1038/srep18065
Autor
Beck
Wladimir Rafael; Botezelli
Jose Diego; Pauli
Jose Rodrigo; Ropelle
Eduardo Rochete; Gobatto
Claudio Alexandre
Institución
Resumen
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) It is well documented that exhaustive physical exercise leads to inflammation and skeletal muscle tissue damage. With this in mind, melatonin has been acutely administered before physical exercise; nevertheless, the use of melatonin as an ergogenic agent to prevent tissue inflammation and damage remains uncertain. We evaluated the effects of melatonin on swimming performance, muscle inflammation and damage and several physiological parameters after exhaustive exercise at anaerobic threshold intensity (iLAn) performed during light or dark circadian periods. The iLAn was individually determined and two days later, the animals performed an exhaustive exercise bout at iLAn 30 minutes after melatonin administration. The exercise promoted muscle inflammation and damage, mainly during the dark period, and the exogenous melatonin promoted a high ergogenic effect. The expressive ergogenic effect of melatonin leads to longer periods of muscle contraction, which superimposes a possible melatonin protective effect on the tissue damage and inflammation. 5
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) FAPESP [2009/08535-5, 2011/13226-1, 2012/20501-1] CNPq [305650/2009-2]