Artículos de revistas
Antifungal Activity Of Extracts And Isolated Compounds From Buchenavia Tomentosa On Candida Albicans And Non-albicans
Registro en:
Antifungal Activity Of Extracts And Isolated Compounds From Buchenavia Tomentosa On Candida Albicans And Non-albicans. Future Medicine Ltd, v. 10, p. 917-927 2015.
1746-0913
WOS:000356025100003
10.2217/FMB.15.20
Autor
Teodoro
Guilherme R.; Brighenti
Fernanda L.; Botazzo Delbem
Alberto C.; Delbem
Adina Cleia B.; Khouri
Sonia; Gontijo
Aline Vidal L.; Pascoal
Aislan C. R. F.; Salvador
Marcos J.; Koga-Ito
Cristiane Y.
Institución
Resumen
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) Aim: This study aimed to evaluate the antifungal activity of Buchenavia tomentosa extract and bioactive compounds on six Candida species. Materials & methods: The antimicrobial activity of extract was evaluated using standard strains and clinical isolates. Cytotoxicity was tested in order to evaluate cell damage caused by the extract. Extract was chemically characterized and the antifungal activity of its compounds was evaluated. Results: Extract showed antifungal activity on Candida species. Candida non-albicans were more susceptible than Candida albicans. Low cytotoxicity for extract was observed. The isolated compounds presented antifungal activity at least against one Candida spp. and all compounds presented antifungal effect on Candida glabrata. Conclusion: Extracts from Buchenavia tomentosa showed promising antifungal activity on Candida species with low cytotoxicity. Gallic acid, corilagin and ellagic acid showed promising inhibitory activity on Candida glabrata. 10 6
917 927 Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)