Artículos de revistas
Serum Interleukin-17 Levels Are Associated With Nephritis In Childhood-onset Systemic Lupus Erythematosus
Registro en:
Serum Interleukin-17 Levels Are Associated With Nephritis In Childhood-onset Systemic Lupus Erythematosus. Hospital Clinicas, Univ Sao Paulo, v. 70, p. 313-317 2015.
1807-5932
WOS:000355800500001
10.6061/clinics/2015(05)01
Autor
Pelicari
Karina de Oliveira; Postal
Mariana; Sinicato
Nailu Angelica; Peres
Fernando Augusto; Fernandes
Paula Teixeira; Marini
Roberto; Lavras Costallat
Lilian Tereza; Appenzeller
Simone
Institución
Resumen
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) OBJECTIVES: To determine the serum interleukin-17 (IL-17) levels in childhood-onset systemic lupus erythematosus patients and to evaluate the association between IL-17 and clinical manifestations, disease activity, laboratory findings and treatment. METHODS: We included 67 consecutive childhood-onset systemic lupus erythematosus patients [61 women; median age 18 years (range 11-31)], 55 first-degree relatives [50 women; median age 40 years (range 29-52)] and 47 age-and sex-matched healthy controls [42 women; median age 19 years (range 6-30)]. The childhood-onset systemic lupus erythematosus patients were assessed for clinical and laboratory systemic lupus erythematosus manifestations, disease activity [Systemic Lupus Erythematosus Disease Activity Index (SLEDAI)], cumulative damage [Systemic Lupus International Collaborating Clinics/American College of Rheumatology (ACR) Damage Index] and current drug use. Serum IL-17 levels were measured by an enzyme-linked immunosorbent assay using commercial kits. RESULTS: The median serum IL-17 level was 36.3 (range 17.36-105.92) pg/mL in childhood-onset systemic lupus erythematosus patients and 29.47 (15.16-62.17) pg/mL in healthy controls (p = 0.009). We observed an association between serum IL-17 levels and active nephritis (p = 0.01) and migraines (p = 0.03). Serum IL-17 levels were not associated with disease activity (p = 0.32), cumulative damage (p = 0.34), or medication use (p = 0.63). CONCLUSION: IL-17 is increased in childhood-onset systemic lupus erythematosus and may play a role in the pathogenesis of neuropsychiatric and renal manifestations. Longitudinal studies are necessary to determine the role of IL-17 in childhood-onset systemic lupus erythematosus. 70 5
313 317 Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) FAPESP [FAPESP 2008/02917-0, 2010/13636-2, 2012/21071-0] CNPq [CNPq 300447/2009-4, 471343/2011-0, 302205/2012-8, 473328/2013-5]