Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Moisture content and particle size are critical parameters in fluidized-bed granulation and coating. In this study, microcrystalline cellulose was granulated and coated. The particle size was monitored in real time by a Parsum IPP70 probe. The fluidization regime was assessed by Gaussian spectral analysis. The bed temperature and gas humidity profile were monitored to evaluate the drying efficiency. The defluidization phase was detected in the early stages with frequencies below 6.0Hz. The Parsum probe showed the growth of the particles due to agglomeration. The psychometric parameters indicated the lower potential energy for drying. Therefore, monitoring in real time is important to detect failures.3315-16 19291948Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)