Artículos de revistas
Molecular And Neuroendocrine Mechanisms Of Cancer Cachexia
Registro en:
Molecular And Neuroendocrine Mechanisms Of Cancer Cachexia. Bioscientifica Ltd, v. 226, p. R29-R43 SEP-2015.
0022-0795
WOS:000360941600002
10.1530/JOE-15-0170
Autor
Mendes
Maria Carolina S.; Pimentel
Gustavo D.; Costa
Felipe O.; Carvalheira
Jose B. C.
Institución
Resumen
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) Cancer and its morbidities, such as cancer cachexia, constitute a major public health problem. Although cancer cachexia has afflicted humanity for centuries, its underlying multifactorial and complex physiopathology has hindered the understanding of its mechanism. During the last few decades we have witnessed a dramatic increase in the understanding of cancer cachexia pathophysiology. Anorexia and muscle and adipose tissue wasting are the main features of cancer cachexia. These apparently independent symptoms have humoral factors secreted by the tumor as a common cause. Importantly, the hypothalamus has emerged as an organ that senses the peripheral signals emanating from the tumoral environment, and not only elicits anorexia but also contributes to the development of muscle and adipose tissue loss. Herein, we review the roles of factors secreted by the tumor and its effects on the hypothalamus, muscle and adipose tissue, as well as highlighting the key targets that are being exploited for cancer cachexia treatment. 226 3
R29 R43 Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) Fundacao de Amparo a Pesquisa de Sao Paulo [2013/07607-8, 2014/22347-5] Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)