Thyroid Imaging Reporting And Data System Score Combined With Bethesda System For Malignancy Risk Stratification In Thyroid Nodules With Indeterminate Results On Cytology

dc.creatorMaia
dc.creatorFrederico F. R.; Matos
dc.creatorPatricia S.; Pavin
dc.creatorElizabeth J.; Zantut-Wittmann
dc.creatorDenise E.
dc.date2015-MAR
dc.date2016-06-07T13:16:53Z
dc.date2016-06-07T13:16:53Z
dc.date.accessioned2018-03-29T01:37:29Z
dc.date.available2018-03-29T01:37:29Z
dc.identifier
dc.identifierThyroid Imaging Reporting And Data System Score Combined With Bethesda System For Malignancy Risk Stratification In Thyroid Nodules With Indeterminate Results On Cytology. Wiley-blackwell, v. 82, p. 439-444 MAR-2015.
dc.identifier0300-0664
dc.identifierWOS:000350115600016
dc.identifier10.1111/cen.12525
dc.identifierhttp://onlinelibrary.wiley.com/doi/10.1111/cen.12525/abstract;jsessionid=FB9EDF6EF68116904A674F6846D81CA5.f04t01
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/242198
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1305896
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.descriptionContextThe thyroid imaging reporting and data system (TI-RADS) was designed to better select patients who had undergone fine-needle aspiration biopsies (FNABs) with high sensitivity and accuracy. However, the combination of TI-RADS scores and Bethesda system categories in indeterminate thyroid nodules has not been examined extensively. ObjectiveThis study aimed to stratify indeterminate thyroid nodules (Bethesda categories III, IV and V) according to risk of malignancy as determined by combining TI-RADS score with Bethesda system classification. DesignRetrospective study. Histopathological, cytological and ultrasound (US) data were available for 242 cases after surgery, including 136 indeterminate nodules. MethodsAll thyroid cytopathological slides and US reports were reviewed and classified according to Bethesda system and TI-RADS categories. The malignancy rate was determined for each Bethesda category, TI-RADS score and both methods combined of indeterminate nodules. ResultsThe malignancy rates were 87%, 513% and 675% for Bethesda categories III, IV and V, respectively. Based on histopathological comparison, the accuracy was 667% for TI-RADS greyscale. TI-RADS 3 and 4A scores were observed in 80% of Bethesda III cases, which led to 80% sensitivity and 90% of negative predictive value (NPV). In contrast, for nodules scored as TI-RADS 4B and 5, the combined cytological results of Bethesda IV and V resulted in a higher risk of malignancy (75% and 769%, respectively, P<0001). ConclusionsIn view of the high NPV of TI-RADS 3/4A only in Bethesda III category, a surgical approach could be considered for lesions defined as Bethesda III, IV and V when TI-RADS 4B and 5 were concomitant.
dc.description82
dc.description3
dc.description
dc.description439
dc.description444
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.descriptionFAPESP [2008/10183-7]
dc.descriptionCAPES [33003017065]
dc.description
dc.description
dc.description
dc.languageen
dc.publisherWILEY-BLACKWELL
dc.publisher
dc.publisherHOBOKEN
dc.relationCLINICAL ENDOCRINOLOGY
dc.rightsfechado
dc.sourceWOS
dc.subjectFine-needle-aspiration
dc.subjectPower Doppler
dc.subjectPredicting Malignancy
dc.subjectClassification-system
dc.subjectCancer-risk
dc.subjectUltrasound
dc.subjectBenign
dc.subjectParameters
dc.subjectSonography
dc.subjectManagement
dc.titleThyroid Imaging Reporting And Data System Score Combined With Bethesda System For Malignancy Risk Stratification In Thyroid Nodules With Indeterminate Results On Cytology
dc.typeArtículos de revistas


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