Artículos de revistas
A Novel Dosage Form For Buccal Administration Of Bupropion
Registration in:
A Novel Dosage Form For Buccal Administration Of Bupropion. Univ Sao Paulo, Conjunto Quimicas, v. 51, p. 91-100 JAN-MAR-2015.
1984-8250
WOS:000357744100010
10.1590/S1984-82502015000100010
Author
Galvao Almeida
Nilsa Maria; Lima
Renata; Ribeiro Alves
Thais Francine; Rebelo
Marcia de Araujo; Severino
Patricia; Chaud
Marco Vinicius
Institutions
Abstract
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) Bupropion is an antidepressant used in the treatment of smoking. The purpose of this study was to prepare controlled-release hydrogel films for buccal administration of bupropion and investigate its physicochemical and cytotoxic properties. The films were prepared from ultrapure sodium carboxymethylcellulose, hydroxypropylmethylcellulose K4M, and medium-viscosity chitosan. Evaluation of film physicochemical characteristics was based on scanning electron microscopy, bupropion content, mechanical strength (burst strength, relaxation, resilience, and traction), and cytotoxicity. Bupropion content in bilayer films was 121 mg per 9 cm(2). The presence of bupropion modified film mechanical strength, but did not compromise the use of this pharmaceutical form. As shown by the cytotoxicity results, films containing bupropion did not cause cellular damage. Bupropion administration in the form of hydrogel films is a potentially useful alternative in the treatment of smoking. 51 1
91 100 Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) FAPESP [2011-21219-5]