Objective: To assess the neurodevelopmental functions (cognition, language and motor function) of survivors of twin-twin transfusion syndrome (TTTS). Method: Observational cross-sectional study of a total of 67 monochorionic diamniotic twins who underwent fetoscopic laser coagulation (FLC) for treatment of TTTS. The study was conducted at the Center for Investigation in Pediatrics (CIPED), Universidade Estadual de Campinas. Ages ranged from one month and four days to two years four months. Bayley Scales of Infant and Toddler Development Screening Test-III, were used for evaluation. Results: Most children reached the competent category and were classified as having appropriate performance. The preterm children scored worse than term infants for gross motor subtest (p = 0.036). Conclusion: The majority of children reached the expected development according to their age. Despite the good neurodevelopment, children classified at risk should be monitored for development throughout childhood. © 2015, Associacao Arquivos de Neuro-Psiquiatria. All rights reserved.733194199Sutcliffe, A.G., Sebire, N.J., Pigott, A.J., Taylor, B., Edwards, P.R., Nicolaides, K.H., Outcome for children born after in utero laser ablation therapy for severe twin-to-twin transfusion syndrome (2011) BJOG, 108 (12), pp. 1246-1250. , http://dx.doi.org/10.1111/j.1471-0528.2001.00294.xKlink, J.M., Koopman, H.M., Oepkes, D., Walther, F.J., Lopriore, E., Long-term neurodevelopmental outcome in monochorionic twins after fetal therapy (2011) Early Hum Dev, 87 (9), pp. 601-606. , http://dx.doi.org/10.1016/j.earlhumdev.2011.07.007Graeve, P., Banek, C., Stegmann-Woessner, G., Maschke, C., Hecher, K., Bartmann, P., Neurodevelopmental outcome at 6 years of age after intrauterine laser therapy for twin-twin transfusion syndrome (2012) Acta Paediatr, 101 (12), pp. 1200-1205. , http://dx.doi.org/10.1111/apa.12017Maschke, C., Diemert, A., Hecher, K., Bartmann, P., Long-term outcome after intrauterine laser treatment for twin-twin transfusion syndrome (2011) Prenat Diagn, 31 (7), pp. 647-653. , http://dx.doi.org/10.1002/pd.2797Roberts, D., Gates, S., Kilby, M., Neilson, J.P., Interventions for twin–twin transfusion syndrome: A Cochrane review (2008) Ultrasound Obstet Gynecol, 31 (6), pp. 701-711Rossi, A.C., Vanderbilt, D., Chmait, R.H., Neurodevelopmental outcomes after laser therapy for twin-twin transfusion syndrome: A systematic review and meta-analysis (2011) Obstet Gynecol, 118 (5), pp. 1145-1150. , http://dx.doi.org/10.1097/AOG.0b013e318231827fChang, Y.L., Chao, A.S., Chang, S.D., Lien, R., Hsieh, P.C., Wang, C., The neurological outcomes of surviving twins in severe twin–twin transfusion syndrome treated by fetoscopic laser photocoagulation at a newly established center (2012) Prenat Diagn, 32 (9), pp. 893-896. , http://dx.doi.org/10.1002/pd.3929Quintero, R.A., Morales, W.J., Allen, M.H., Bornick, P.W., Johnson, P.K., Kruger, M., Staging of twin-twin transfusion syndrome (1999) J Perinatol, 19 (8), pp. 550-555. , http://dx.doi.org/10.1038/sj.jp.7200292Bayley, N., (2006) Screening Test of Bayley Scales of Infant and Toddler Development-Iii, , San Antonio: PearsonDiament, A., Cypel, S., (2005) Neurologia Infantil, , 4th ed. Rio de Janeiro: AtheneuGraef, C., Ellenrieder, B., Hecher, K., Hackeloer, B.J., Huber, A., Bartmann, P., Long-term neurodevelopmental outcome of 167 children after intrauterine laser treatment for severe twin-twin transfusion syndrome (2006) Am J Obstet Gynecol, 194 (2), pp. 303-308. , http://dx.doi.org/10.1016/j.ajog.2005.07.040Lopriore, E., Middeldorp, J.M., Sueters, M., Oepkes, D., Vandenbussche, F.P., Walther, F.J., Long-term neurodevelopmental outcome in twin-to-twin transfusion syndrome treated with fetoscopic laser surgery (2007) Am J Obstet Gynecol, 196 (3), p. 231. , http://dx.doi.org/10.1016/j.ajog.2006.10.906Banek, C.S., Hecher, K., Hackeloer, B.J., Bartmann, P., Long-term neurodevelopmental outcome after intrauterine laser treatment for severe twin-twin transfusion syndrome (2003) Am J Obstet Gynecol, 188 (4), pp. 876-880. , http://dx.doi.org/10.1067/mob.2003.202Lopriore, E., Nagel, H.T., Vandenbussche, F.P., Walther, F.J., Long-term neurodevelopmental outcome in twin-to-twin transfusion syndrome (2003) Am J Obstet Gynecol, 189 (5), pp. 1314-1319. , http://dx.doi.org/10.1067/S0002-9378(03)00760-9Lopriore, E., Sueters, M., Middeldorp, J.M., Oepkes, D., Vandenbussche, F.P., Walther, F.J., Neonatal outcome in twin-to-twin transfusion syndrome treated with fetoscopic laser occlusion of vascular anastomoses (2005) J Pediatr, 147 (5), pp. 597-602. , http://dx.doi.org/10.1016/j.jpeds.2005.06.004Wagner, M.M., Lopriore, E., Klumper, F.J., Oepkes, D., Vandenbussche, F.P., Middeldorp, J.M., Short- and long-term outcome in stage 1 twin-totwin transfusion syndrome treated with laser surgery compared with conservative management (2009) Am J Obstet Gynecol, 201 (3), p. 86. , http://dx.doi.org/10.1016/j.ajog.2009.05.034Lenclen, R., Ciarlo, G., Paupe, A., Bussieres, L., Ville, Y., Neurodevelopmental outcome at 2 years in children born preterm treated by amnioreduction or fetoscopic laser surgery for twin-to-twin transfusion syndrome: Comparison with dichorionic twins (2009) Am J Obstet Gynecol, 201 (3), p. 291. , http://dx.doi.org/10.1016/j.ajog.2009.05.036Ortibus, E., Lopriore, E., Deprest, J., Vandenbussche, F.P., Walther, F.J., Diemert, A., The pregnancy and long-term neurodevelopmental outcome of monochorionic diamniotic twin gestations: A multicenter prospective cohort study from the first trimester onward (2009) Am J Obstet Gynecol, 200 (5), p. 494. , http://dx.doi.org/10.1016/j.ajog.2009.01.048De Lia, J.E., Kuhlmann, R.S., Lopez, K.P., Treating previable twin-twin transfusion syndrome with fetoscopic laser surgery: Outcomes following the learning curve (1999) J Perinat Med, 27 (1), pp. 61-67. , http://dx.doi.org/10.1515/JPM.1999.007Duncombe, G.J., Dickinson, J.E., Evans, S.F., Perinatal characteristics and outcomes of pregnancies complicated by twin–twin transfusion syndrome (2003) Obstet Gynecol, 101 (6), pp. 1190-1196. , http://dx.doi.org/10.1016/S0029-7844(03)00231-XPeralta, C.F., Ishikawa, L.E., Bennini, J.R., Braga, A., Rosa, I., Biondi, M.C., Ablação dos vasos placentários com laser para tratamento da síndrome de transfusão feto-fetal grave: Experiência de um centro universitário no Brasil (2010) Rev Bras Ginecol Obstet, 32 (5), pp. 214-221. , http://dx.doi.org/10.1590/S0100-72032010000500003Vanderbilt, D.L., Schrager, S.M., Llanes, A., Chmait, R.H., Revalence and risk factors of cerebral lesions in neonates after laser surgery for twintwin transfusion syndrome (2012) Am J Obstet Gynecol, 207 (4), p. 320. , http://dx.doi.org/10.1016/j.ajog.2012.06.031Schlapbach, L.J., Adams, M., Proietti, E., Aebischer, M., Grunt, S., Borradori-Tolsa, C., Outcome at two years of age in a Swiss national cohort of extremely preterm infants born between 2000 and 2008 (2012) BMC Pediatr, 12 (198), p. 198. , http://dx.doi.org/10.1186/1471-2431-12-198Kynø, N.M., Ravn, I.H., Lindemann, R., Fagerlande, M.W., Smebyf, N.A., Torgersen, A.M., Effect of an early intervention programme on development of moderate and late preterm infants at 36 months: A randomized controlled study (2012) Infant Behav Dev, 35 (4), pp. 916-926. , http://dx.doi.org/10.1016/j.infbeh.2012.09.004Yang, H., Einspieler, C., Shi, W., Marschik, P.B., Wang, Y., Cao, Y., Cerebral palsy in children: Movements and postures during early infancy, dependent on preterm vs. Full term birth (2012) Early Hum Dev, 88 (10), pp. 837-843. , http://dx.doi.org/10.1016/j.earlhumdev.2012.06.004Himpens, E., Van Den Broeck, C., Oostra, A., Vanhaesebrouck, P., Prevalence, type, distribution, and severity of cerebral palsy in relation to gestational age: A meta-analytic review (2008) Dev Med Child Neuro, 50 (5), pp. 334-340. , http://dx.doi.org/10.1111/j.1469-8749.2008.02047.xHaastert, I.C., De Vries, L.S., Helders, P.J., Jongmans, M.J., Early gross motor development of preterm infants according to the Alberta Infant Motor Scale (2006) J Pediatr, 149 (5), pp. 617-622. , http://dx.doi.org/10.1016/j.jpeds.2006.07.025Lind, A., Parkkola, R., Lehtonen, L., Munck, P., Maunu, J., Lapinleimu, H., Associations between regional brain volumes at term-equivalent age and development at 2 years of age in preterm children (2011) Pediatr Radiol, 41 (8), pp. 953-961. , http://dx.doi.org/10.1007/s00247-011-2071-xKieviet, J.F., Zoetebier, L., Elburg, R.M., Vermeulen, R.J., Osterlaan, J., Brain development of very preterm and very low-birthweight children in childhood and adolescence: A meta-analysis (2012) Dev Med Child Neurol, 54 (4), pp. 313-323. , http://dx.doi.org/10.1111/j.1469-8749.2011.04216.xDe Vis, J.B., Petersen, E.T., Vries, L.S., Groenendaal, F., Kersbergen, K.J., Alderliesten, T., Regional changes in brain perfusion during brain maturation measured non-invasively with Arterial Spin Labeling MRI in neonates (2013) Eur J Radiol, 82 (3), pp. 538-543. , http://dx.doi.org/10.1016/j.ejrad.2012.10.013