Artículos de revistas
Cytotoxicity And Chemical Composition Of The Essential Oils Of Magnolia Ovata
Registro en:
Latin American Journal Of Pharmacy. Colegio De Farmaceuticos De La Provincia De Buenos Aires, v. 35, n. 1, p. 206 - 209, 2016.
3262383
2-s2.0-84949936863
Institución
Resumen
The essential oils, isolated by hydrodistillation from dried leaves and trunk bark of Magnolia ovata (A. St.-Hil.) Spreng. (syn. Talauma ovata A. St.-Hil.), were evaluated for cytotoxic activity in vitro against U251 (glioma), UACC-62 (melanoma), MCF-7 (breast), NCI-H460 (lung), PC-3 (prostate), and K562 (leukemia) human cancer cells and, also against HaCat (no cancer cell line) using the sulforhodamine B method. Both oils exhibited activity, being U251, MCF-7, and PC-3 the more susceptible cells. The oils were analyzed by GC-FID and GC/MS. Forty-one compounds were identified, representing around 90% of total oils. The major components were spathulenol (leaves: 39.5%; trunk bark: 38.9%) and β-eudesmol (leaves: 17.6%; trunk bark: 17.8%). © 2015, Colegio de Farmaceuticos de la Provincia de Buenos Aires. All rights reserved. 35 1 206 209 Azuma, H., Thien, L.B., Kawano, S., (1999) J. Plant Res., 112, pp. 291-306 Mello-Silva, R., Magnoliaceae (2015) Lista de espécies da Flora do Brasil, , http://floradobrasil.jbrj.gov.br/jabot/floradobrasil/FB8795 Mors, W.B., Rizzini, C.T., Pereira, N.A., (2002) Medicinal Plants of Brazil, 216p. , Reference Publications, Algonac Tomazi, L.B., Aguiar, P.A., Citadini-Zanete, V., Rossato, A.E., (2014) Rev. Bras. Pl. Med., 16, pp. 450-461 Stefanello, M.E.A., Alvarenga, M.A., (1997) Fitoterapia, 68, pp. 475-476 Stefanello, M.E.A., Alvarenga, M.A., Toma, I.N., (2002) Fitoterapia, 73, pp. 135-139 Stefanello, M.E.A., Mello-Silva, R., (2005) J. Essent. Oil Res., 17, pp. 455-456 Stefanello, M.E.A., Salvador, M.J., Ito, I.Y., Wisniewski, A., Jr., Simionatto, E.L., Mello-Silva, R., (2008) J. Essent. Oil Res., 20, pp. 565-569 Stefanello, M.E.A., Salvador, M.J., Ito, I.Y., Montoia, A., Silva, C.J.F., Barros, L.F.L., (2009) Lat. Am. J. Pharm., 28, pp. 270-274 Barros, L.F.L., Barison, A., Salvador, M.J., Mello-Silva, R., Cabral, E.C., Eberlin, M.N., (2009) J. Nat. Prod., 72, pp. 1529-1532 Apel, M.A., Lima, M.E.L., Moreno, P.R.H., Young, M.C.M., Cordeiro, I., Henriques, A.T., (2009) J. Essent. Oil Res., 21, pp. 52-53 Barros, L.F.L., Erenfried, C.A., Riva, D., Barison, A., Mello-Silva, R., Stefanello, M.E.A., (2012) Nat. Prod. Comm., 7, pp. 1365-1367 Gottsberger, G., Silberbauer-Gottsberger, I., Seymour, R.S., Dötterl, S., (2012) Flora, 207, pp. 107-118 Kassuya, C.A.L., Cremoneze, A., Barros, L.F.L., Simas, A.S., Lapa, F.R., Mello-Silva, R., (2009) J. Ethnopharmacol., 124, pp. 369-376 Mori, L.S., Boller, S., Kassuya, C.A.L., Stefanello, M.E.A., Zampronio, A.R., (2011) Phytomedicine, 18, pp. 143-147 Adams, R.P., (2007) Identification of Essential Oils Components by Gas chromatography/ Mass Spectrometry, , Allured Publ. Corp., Carol Stream Skehan, P., Storeng, R., Scudiero, D., Monks, A., McMahon, J., Vistica, D., (1990) J. Natl. Cancer Inst., 82, pp. 1107-1118 Menezes, C.B.A., Silva, B.P., Sousa, I.M.O., Ruiz, A.L.T.G., Spindola, H.M., Cabral, E., (2013) Braz. J. Med. Biol. Res., 46, pp. 45-65 Fullas, F., Hussain, R.A., Chai, H., Pezzuto, J.M., Soejarto, D.D., Kinghorn, D., (1994) J. Nat. Prod., 57, pp. 801-807 Fukuda, M., Ohkoshi, E., Makino, M., Fujimoto, Y., (2006) Chem. Pharm. Bull., 54, pp. 1465-1468 Pacciaroni, A.D., Mongelli, E., Espinar, L.A., Romano, A., Ciccia, G., Silva, G.L., (2000) Planta Med., 66, pp. 720-723 Matos, M.F.C., Leite, L.I.S.P., Brustolim, D., Siqueira, J.M., Carollo, C.A., Hellmann, A.R., (2006) Fitoterapia, 77, pp. 227-229 Suresh, G., Poornima, B., Suresh, B.K., Yadav, P.A., Rao, M.S.A., Siva, B., (2013) Fitoterapia, 86, pp. 100-107 You, C., Yang, K., Wang, C., Zhang, W., Wang, Y., Han, J., (2014) Molecules, 19, pp. 13225-13234 Li, Y., Miao, C., Li, J., Xiao, W., Ma, E., (2013) Phytother. Res., 27, pp. 338-348 Bomfim, D., Ferraz, R.P.C., Carvalho, N.C., Soares, M.B.P., Pinheiro, M.L.B., Costa, E.V., (2013) Basic Clin. Pharmacol. Toxicol., 113, pp. 300-306 Park, K., Nam, D., Yun, H., Lee, S., Jang, H., Sethi, G., (2011) Cancer Let., 312, pp. 178-188