Paucity Of Plasmodium Vivax Mature Schizonts In Peripheral Blood Is Associated With Their Increased Cytoadhesive Potential.

dc.creatorLopes, Stefanie C P
dc.creatorAlbrecht, Letusa
dc.creatorCarvalho, Bruna O
dc.creatorSiqueira, André M
dc.creatorThomson-Luque, Richard
dc.creatorNogueira, Paulo A
dc.creatorFernandez-Becerra, Carmen
dc.creatorDel Portillo, Hernando A
dc.creatorRussell, Bruce M
dc.creatorRénia, Laurent
dc.creatorLacerda, Marcus V G
dc.creatorCosta, Fabio T M
dc.date2014-May
dc.date2015-11-27T13:41:46Z
dc.date2015-11-27T13:41:46Z
dc.date.accessioned2018-03-29T01:19:33Z
dc.date.available2018-03-29T01:19:33Z
dc.identifierThe Journal Of Infectious Diseases. v. 209, n. 9, p. 1403-7, 2014-May.
dc.identifier1537-6613
dc.identifier10.1093/infdis/jiu018
dc.identifierhttp://www.ncbi.nlm.nih.gov/pubmed/24415786
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/201087
dc.identifier24415786
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1301320
dc.descriptionThere is now a growing body of evidence that challenges the current view that Plasmodium vivax-infected erythrocyte (Pv-iE) are unable to sequester. Here we used ex vivo adhesion assays with Pv-iE before and after maturation to demonstrate a higher binding potential of schizonts compared to other asexual stages. These experimental results are correlated with our observations in a panel of 50 vivax malaria patients where schizonts were completely absent in 27 isolates, and few schizonts were observed in the remaining patients. These observations prompt a paradigm shift in P. vivax biology and open avenues to investigate the role of Pv-iE sequestration.
dc.description209
dc.description1403-7
dc.languageeng
dc.relationThe Journal Of Infectious Diseases
dc.relationJ. Infect. Dis.
dc.rightsfechado
dc.rights
dc.sourcePubMed
dc.subjectAntimalarials
dc.subjectCell Adhesion
dc.subjectChloroquine
dc.subjectErythrocytes
dc.subjectHumans
dc.subjectMalaria, Vivax
dc.subjectParasitemia
dc.subjectPlasmodium Vivax
dc.subjectPrimaquine
dc.subjectSchizonts
dc.subjectStatistics, Nonparametric
dc.subjectPlasmodium Vivax
dc.subjectCytoadhesion
dc.subjectDisproportionality
dc.subjectMalaria
dc.subjectSchizonts
dc.subjectSequestration
dc.titlePaucity Of Plasmodium Vivax Mature Schizonts In Peripheral Blood Is Associated With Their Increased Cytoadhesive Potential.
dc.typeArtículos de revistas


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