Artículos de revistas
Radioprotective Effect Of Sodium Selenite On Developing Teeth.
Registro en:
Brazilian Dental Journal. v. 24, n. 4, p. 375-9, 2013.
1806-4760
10.1590/0103-6440201302193
24173260
Autor
Neves, Ellen Gaby
Ramos-Perez, Flávia Maria de Moraes
Freitas, Deborah Queiroz
Bóscolo, Frab Norberto
Almeida, Solange Maria
Institución
Resumen
Radioprotective agents like selenium are used to reduce the damage caused by radiation in healthy tissues. The aim of this study was to evaluate the effect of sodium selenite on the development of the molars of offspring of rats irradiated during odontogenesis. Twenty pregnant rats were randomly divided into 4 groups: control, irradiated, selenium and selenium/irradiated. The selenium and selenium/irradiated groups received 0.3 mg/kg of sodium selenite at 18 days of pregnancy. The rats of the irradiated and selenium/irradiated groups received a single dose of 4 Gy of X rays on the abdominal region at the 19th day of pregnancy. The offspring was sacrificed at 3 and 4 days after birth for evaluation of the birefringence of the enamel organic matrix, and at 30 days for evaluation of the intercuspal dimensions of the molars. The selenium/irradiated group was similar to the irradiated group with respect to the thickness and irregularity of the enamel organic matrix region in the evaluated birefringence, as the intercuspal dimensions of the molars. In conclusion, sodium selenite had no radioprotective action on the development of the molars of offspring of rats irradiated during odontogenesis and had a toxic effect in the initial time. 24 375-9