Mechanical And Morphological Aspects Of The Calcaneal Tendon Of Mdx Mice At 21 Days Of Age.

dc.creatorNakagaki, Wilson Romero
dc.creatorTomiosso, Tatiana Carla
dc.creatorPimentel, Edson Rosa
dc.creatorCamilli, José Angelo
dc.date2013-Oct
dc.date2015-11-27T13:32:04Z
dc.date2015-11-27T13:32:04Z
dc.date.accessioned2018-03-29T01:18:21Z
dc.date.available2018-03-29T01:18:21Z
dc.identifierAnatomical Record (hoboken, N.j. : 2007). v. 296, n. 10, p. 1546-51, 2013-Oct.
dc.identifier1932-8494
dc.identifier10.1002/ar.22759
dc.identifierhttp://www.ncbi.nlm.nih.gov/pubmed/23934706
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/200780
dc.identifier23934706
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1301013
dc.descriptionA relationship between compromised muscles and other tissues has been demonstrated in mdx mouse, an animal model studied for understanding of Duchenne muscular dystrophy. The hypothesis is that changes in the calcaneal tendon of mdx mice occur previous to the onset of rigorous and most marked episodes of muscle degeneration, which start suddenly after 21 days of life. Thus, this study aimed to identify possible alterations in the calcaneal tendon of mdx mouse at 21 days of age. Control and mdx tendons were submitted to mechanical tensile testing, quantification of hydroxyproline, and staining with toluidine blue and picrosirius red. Hydroxyproline content was similar between mdx and control groups. The control tendon presented higher mechanical strength (load, stress, and elastic modulus) and its morphological analysis showed a larger number of round fibroblasts, nuclei with well-decondensed chromatin, and slightly metachromatic well-stained cytoplasmic material, different from that observed in mdx tendons. The results suggest that the absence of dystrophin in mdx mouse can provoke directly or indirectly alterations in the mechanical properties and morphology of the calcaneal tendon.
dc.description296
dc.description1546-51
dc.languageeng
dc.relationAnatomical Record (hoboken, N.j. : 2007)
dc.relationAnat Rec (Hoboken)
dc.rightsfechado
dc.rightsCopyright © 2013 Wiley Periodicals, Inc.
dc.sourcePubMed
dc.subjectAnimals
dc.subjectBiomechanical Phenomena
dc.subjectCalcaneus
dc.subjectDisease Models, Animal
dc.subjectHydroxyproline
dc.subjectMale
dc.subjectMice
dc.subjectMice, Inbred C57bl
dc.subjectMice, Inbred Mdx
dc.subjectMuscle, Skeletal
dc.subjectMuscular Dystrophies
dc.subjectStress, Mechanical
dc.subjectTendons
dc.subjectTensile Strength
dc.subjectMdx Mice
dc.subjectMechanical Properties
dc.subjectMorphology
dc.subjectMuscular Dystrophy
dc.titleMechanical And Morphological Aspects Of The Calcaneal Tendon Of Mdx Mice At 21 Days Of Age.
dc.typeArtículos de revistas


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