Artículos de revistas
Etiologic And Diagnostic Evaluation: Algorithm For Severe To Profound Sensorineural Hearing Loss In Brazil.
Registro en:
International Journal Of Audiology. v. 52, n. 11, p. 746-52, 2013-Nov.
1708-8186
10.3109/14992027.2013.817689
23909750
Autor
Ramos, Priscila Zonzini
de Moraes, Vanessa Cristine Sousa
Svidnicki, Maria Carolina Costa Melo
Soki, Marcelo Naoki
Castilho, Arthur Menino
Sartorato, Edi Lúcia
Institución
Resumen
Evaluation of the effectiveness of imaging and genetic testing, and establishment of a cost-effective diagnostic protocol for the etiologic diagnosis of sensorineural hearing loss (SNHL) in Brazil. Prospective cohort study. Analysis of 100 unrelated Brazilian patients with severe to profound bilateral SNHL submitted to cochlear implant (CI) between 2002 and 2010 at the University of Campinas hospital. The study was based upon three groups: individuals with congenital, progressive, and sudden SNHL. After the diagnostic investigation, the number of cases with unknown etiology was reduced from 72 to 42 (a 42% reduction); 25% of cases were due to environmental factors, 19% to genetic causes, and 14% to inner-ear abnormalities or other clinical features. The genetic and imaging findings contributed to the diagnosis of SNHL in 19% and 20% of the cases analysed, respectively. Molecular testing mainly contributed to the diagnosis of patients with congenital SNHL, while the contribution of radiologic examination was higher for individuals with progressive or sudden SNHL. A sequential diagnostic protocol was proposed based on these data. The proposed diagnostic workup algorithm could provide better optimization of etiologic diagnosis, as well as reduced costs, compared to a simultaneous testing approach. 52 746-52