Anti-inflammatory And Antimicrobial Evaluation Of Neovestitol And Vestitol Isolated From Brazilian Red Propolis.

dc.creatorBueno-Silva, Bruno
dc.creatorAlencar, Severino M
dc.creatorKoo, Hyun
dc.creatorIkegaki, Masaharu
dc.creatorSilva, Gil V J
dc.creatorNapimoga, Marcelo H
dc.creatorRosalen, Pedro L
dc.date2013-May
dc.date2015-11-27T13:31:39Z
dc.date2015-11-27T13:31:39Z
dc.date.accessioned2018-03-29T01:17:39Z
dc.date.available2018-03-29T01:17:39Z
dc.identifierJournal Of Agricultural And Food Chemistry. v. 61, n. 19, p. 4546-50, 2013-May.
dc.identifier1520-5118
dc.identifier10.1021/jf305468f
dc.identifierhttp://www.ncbi.nlm.nih.gov/pubmed/23607483
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/200598
dc.identifier23607483
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1300831
dc.descriptionThe objective of this study was to evaluate anti-inflammatory and antimicrobial activities of neovestitol and vestitol isolated from Brazilian red propolis (BRP). BRP ethanolic extract (EEP), neovestitol, and vestitol were evaluated by anti-inflammatory properties using a neutrophil migration assay. The antimicrobial activity was evaluated by minimal inhibitory and bactericidal concentrations (MIC and MBC) against Streptococcus mutans , Streptococcus sobrinus , Staphylococcus aureus , and Actinomyces naeslundii . Neovestitol, vestitol, and EEP inhibited neutrophil migration at a dose of 10 mg/kg. Regarding antimicrobial activity, neovestitol showed MICs ranging from <6.25 to 25-50 μg/mL and MBCs ranging from 25-50 to 50-100 μg/mL, while vestitol showed MICs ranging from 25-50 to 50-100 μg/mL and MBCs ranging from 25-50 to 50-100 μg/mL. Both isoflavonoids neovestitol and vestitol are consistent bioactive compounds displaying anti-inflammatory and antimicrobial activities that can strongly act in a low dose and concentration and have a promising potential to be applied in the pharmaceutical and food industries.
dc.description61
dc.description4546-50
dc.languageeng
dc.relationJournal Of Agricultural And Food Chemistry
dc.relationJ. Agric. Food Chem.
dc.rightsfechado
dc.rights
dc.sourcePubMed
dc.subjectActinomyces
dc.subjectAnimals
dc.subjectAnti-infective Agents
dc.subjectAnti-inflammatory Agents
dc.subjectBrazil
dc.subjectFlavonoids
dc.subjectInflammation
dc.subjectMale
dc.subjectMice
dc.subjectMice, Inbred Balb C
dc.subjectMicrobial Sensitivity Tests
dc.subjectPropolis
dc.subjectStaphylococcus Aureus
dc.subjectStreptococcus Mutans
dc.subjectStreptococcus Sobrinus
dc.titleAnti-inflammatory And Antimicrobial Evaluation Of Neovestitol And Vestitol Isolated From Brazilian Red Propolis.
dc.typeArtículos de revistas


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