Age-related Changes In Dystrophin-glycoprotein Complex And In Utrophin Are Not Correlated With Intrinsic Laryngeal Muscles Protection In Mdx Mice.

Ferretti, Renato; Pertille, Adriana; Santo Neto, Humberto; Marques, Maria Julia

Artículos de revistas

Registro en:

Muscle & Nerve. v. 44, n. 6, p. 978-80, 2011-Dec.

1097-4598

10.1002/mus.22235

http://www.ncbi.nlm.nih.gov/pubmed/22102469

http://repositorio.unicamp.br/jspui/handle/REPOSIP/199697

22102469

http://repositorioslatinoamericanos.uchile.cl/handle/2250/1299930

Autor

Ferretti, Renato

Pertille, Adriana

Santo Neto, Humberto

Marques, Maria Julia

Institución

Universidade Estadual de Campinas (Brasil)

Resumen

In this study we investigate whether dystrophic intrinsic laryngeal muscles (ILM) from aged mdx mice show alterations in dystrophin-glycoprotein complex (DGC) components.Immunofluorescence and immunoblotting analyses of beta-sarcoglycan, beta-dystroglycan, and utrophin showed that aged ILM had a similar pattern of changes in aged affected muscles (diaphragm and limb), suggesting that aging leads to changes in utrophin and DGC proteins in dystrophic ILM that cannot be correlated with their protection from dystrophic change.

978-80