[erbb-2 Expression And Hormone Receptor Status In Areas Of Transition From In Situ To Invasive Ductal Breast Carcinoma].

dc.creatorPeres, Raquel Mary Rodrigues
dc.creatorDerchain, Sophie Françoise Mauricette
dc.creatorHeinrich, Juliana Karina Ruiz
dc.creatorSerra, Kátia Piton
dc.creatorPinto, Glauce Aparecida
dc.creatorSoares, Fernando Augusto
dc.creatorSarian, Luís Otávio Zanatta
dc.date2009-Sep
dc.date2015-11-27T13:15:38Z
dc.date2015-11-27T13:15:38Z
dc.date.accessioned2018-03-29T01:09:35Z
dc.date.available2018-03-29T01:09:35Z
dc.identifierRevista Brasileira De Ginecologia E Obstetrícia : Revista Da Federação Brasileira Das Sociedades De Ginecologia E Obstetrícia. v. 31, n. 9, p. 461-7, 2009-Sep.
dc.identifier1806-9339
dc.identifier
dc.identifierhttp://www.ncbi.nlm.nih.gov/pubmed/19876578
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/198517
dc.identifier19876578
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1298750
dc.descriptionto evaluate the expression of erbB-2 and of the estrogen and progesterone (ER/P) hormonal receptors in the transition regions between the in situ and the invasive fractions of ductal breast neoplasia (ISDC and IDC, respectively). Eighty-five cases of breast neoplasia, containing contiguous ISDC and IDC areas, were selected. Histological specimens from the ISDC and the IDC areas were obtained through the tissue microarray (TMA) technique. The erbB-2 and the ER/PR expressions were evaluated through conventional immunohistochemistry. The McNemar's test was used for the comparative analysis of the expressions of erbB-2 protein and the ER/PR in the in situ and invasive regions of the tumors. The confidence intervals were set to 5% (p=0.05). Intraclass correlation coefficients (ICC) were calculated to assess the cross-tabulation agreement of the erbB-2 and the ER/PR expression in the ISDC and the IDC areas. the erbB-2 expression has not differed between the ISDC and the IDC areas (p=0.38). Comparing the two areas in each case, there was agreement in the expression of erbB-2 (ICC=0.64), PR (ICC=0.71) and ER (ICC=0.64). Restricting the analysis to tumors with the in situ component harboring necrosis (comedo), the ICC for erbB-2 was 0.4, compared to 0.6 for the whole sample. In this select group, the ICC for PR/ER did not differ substantially from those obtained with the complete dataset: as for the ER, ICC=0.7 (versus 0.7 for the entire sample) and for PR, ICC=0.7 (versus 0.6 for the entire sample). our findings suggest that the erbB-2 and the ER/PR expressions do not differ in the contiguous in situ and invasive components of breast ductal tumors.
dc.description31
dc.description461-7
dc.languagepor
dc.relationRevista Brasileira De Ginecologia E Obstetrícia : Revista Da Federação Brasileira Das Sociedades De Ginecologia E Obstetrícia
dc.relationRev Bras Ginecol Obstet
dc.rightsaberto
dc.rights
dc.sourcePubMed
dc.subjectBreast Neoplasms
dc.subjectCarcinoma, Ductal, Breast
dc.subjectCarcinoma, Intraductal, Noninfiltrating
dc.subjectCross-sectional Studies
dc.subjectFemale
dc.subjectHumans
dc.subjectMiddle Aged
dc.subjectReceptor, Erbb-2
dc.subjectReceptors, Estrogen
dc.subjectReceptors, Progesterone
dc.title[erbb-2 Expression And Hormone Receptor Status In Areas Of Transition From In Situ To Invasive Ductal Breast Carcinoma].
dc.typeArtículos de revistas


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