Expression Profiling Of Drosophila Mitochondrial Genes Via Deep Mrna Sequencing.

dc.creatorTorres, Tatiana Teixeira
dc.creatorDolezal, Marlies
dc.creatorSchlötterer, Christian
dc.creatorOttenwälder, Birgit
dc.date2009-Dec
dc.date2015-11-27T13:15:37Z
dc.date2015-11-27T13:15:37Z
dc.date.accessioned2018-03-29T01:09:33Z
dc.date.available2018-03-29T01:09:33Z
dc.identifierNucleic Acids Research. v. 37, n. 22, p. 7509-18, 2009-Dec.
dc.identifier1362-4962
dc.identifier10.1093/nar/gkp856
dc.identifierhttp://www.ncbi.nlm.nih.gov/pubmed/19843606
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/198506
dc.identifier19843606
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1298739
dc.descriptionMitochondria play an essential role in several cellular processes. Nevertheless, very little is known about patterns of gene expression of genes encoded by the mitochondrial DNA (mtDNA). In this study, we used next-generation sequencing (NGS) for transcription profiling of genes encoded in the mitochondrial genome of Drosophila melanogaster and D. pseudoobscura. The analysis of males and females in both species indicated that the expression pattern was conserved between the two species, but differed significantly between both sexes. Interestingly, mRNA levels were not only different among genes encoded by separate transcription units, but also showed significant differences among genes located in the same transcription unit. Hence, mRNA abundance of genes encoded by mtDNA seems to be heavily modulated by post-transcriptional regulation. Finally, we also identified several transcripts with a noncanonical structure, suggesting that processing of mitochondrial transcripts may be more complex than previously assumed.
dc.description37
dc.description7509-18
dc.languageeng
dc.relationNucleic Acids Research
dc.relationNucleic Acids Res.
dc.rightsaberto
dc.rights
dc.sourcePubMed
dc.subjectAnimals
dc.subjectChromosome Mapping
dc.subjectDna, Mitochondrial
dc.subjectDrosophila
dc.subjectDrosophila Proteins
dc.subjectDrosophila Melanogaster
dc.subjectExpressed Sequence Tags
dc.subjectFemale
dc.subjectGene Expression Profiling
dc.subjectGenes, Mitochondrial
dc.subjectGenes, Rrna
dc.subjectMale
dc.subjectRna, Messenger
dc.subjectSequence Analysis, Rna
dc.titleExpression Profiling Of Drosophila Mitochondrial Genes Via Deep Mrna Sequencing.
dc.typeArtículos de revistas


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