Artículos de revistas
Long-term Therapy With Deflazacort Decreases Myocardial Fibrosis In Mdx Mice.
Muscle & Nerve. v. 40, n. 3, p. 466-8, 2009-Sep.
Marques, Maria Julia
Oggiam, Daniella Silva
Barbin, Isabel Cristina Chagas
Santo Neto, Humberto
We evaluated the effects of long-term administration of deflazacort (DFZ) on the progression of myocardial fibrosis in mdx mice. Mdx mice (6 months old) were treated with DFZ for 15 months. Myocardial fibrosis (MF) was evaluated by histomorphometric methods, and treated and untreated mdx mice of the same age (21 months) were compared. DFZ significantly decreased MF. We conclude that long-term therapy with DFZ is effective in slowing down the progression of fibrosis in the dystrophin-deficient heart.40466-8