Identification Of A Bioactive Compound Isolated From Brazilian Propolis Type 6.

Castro, Myrella Lessio; do Nascimento, Andréa Mendes; Ikegaki, Masaharu; Costa-Neto, Cláudio M; Alencar, Severino M; Rosalen, Pedro L

Artículos de revistas

Registro en:

Bioorganic & Medicinal Chemistry. v. 17, n. 14, p. 5332-5, 2009-Jul.

1464-3391

10.1016/j.bmc.2009.04.066

http://www.ncbi.nlm.nih.gov/pubmed/19497755

http://repositorio.unicamp.br/jspui/handle/REPOSIP/198350

19497755

http://repositorioslatinoamericanos.uchile.cl/handle/2250/1298583

Autor

Castro, Myrella Lessio

do Nascimento, Andréa Mendes

Ikegaki, Masaharu

Costa-Neto, Cláudio M

Alencar, Severino M

Rosalen, Pedro L

Institución

Universidade Estadual de Campinas (Brasil)

Resumen

A prenylated benzophenone, hyperibone A, was isolated from the hexane fraction of Brazilian propolis type 6. Its structure was determined by spectral analysis including 2D NMR. This compound exhibited cytotoxic activity against HeLa tumor cells (IC(50)=0.1756microM), strong antimicrobial activity (MIC range-0.73-6.6microg/mL; MBC range-2.92-106microg/mL) against Streptococcus mutans, Streptococcus sobrinus, Streptococcus oralis, Staphylococcus aureus, and Actinomyces naeslundii, and the results of its cytotoxic and antimicrobial activities were considered good.

5332-5