Microrna Expression Profile In Murine Central Nervous System Development.

dc.creatorDogini, Danyella B
dc.creatorRibeiro, Patrícia A O
dc.creatorRocha, Cristiane
dc.creatorPereira, Tiago C
dc.creatorLopes-Cendes, Iscia
dc.date2008-Jul
dc.date2015-11-27T13:12:47Z
dc.date2015-11-27T13:12:47Z
dc.date.accessioned2018-03-29T01:06:45Z
dc.date.available2018-03-29T01:06:45Z
dc.identifierJournal Of Molecular Neuroscience : Mn. v. 35, n. 3, p. 331-7, 2008-Jul.
dc.identifier0895-8696
dc.identifier10.1007/s12031-008-9068-4
dc.identifierhttp://www.ncbi.nlm.nih.gov/pubmed/18452032
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/197789
dc.identifier18452032
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1298022
dc.descriptionMicroRNAs (miRNAs) regulate gene expression in a post-transcriptional sequence-specific manner. In order to better understand the possible roles of miRNAs in central nervous system (CNS) development, we examined the expression profile of 104 miRNAs during murine brain development. We obtained brain samples from animals at embryonic days (E) E15, E17, and postnatal days (P) P1 and P7. Total RNA was isolated from tissue and used to obtain mature miRNAs by reverse transcription. Our results indicate that there is a group of 12 miRNAs that show a distinct expression profile, with the highest expression during embryonic stages and decreasing significantly during development. This profile suggests key roles in processes occurring during early CNS development.
dc.description35
dc.description331-7
dc.languageeng
dc.relationJournal Of Molecular Neuroscience : Mn
dc.relationJ. Mol. Neurosci.
dc.rightsfechado
dc.rights
dc.sourcePubMed
dc.subjectAnimals
dc.subjectBrain Chemistry
dc.subjectCentral Nervous System
dc.subjectGene Expression Profiling
dc.subjectGene Expression Regulation, Developmental
dc.subjectMice
dc.subjectMice, Inbred Balb C
dc.subjectMicrornas
dc.subjectReverse Transcriptase Polymerase Chain Reaction
dc.titleMicrorna Expression Profile In Murine Central Nervous System Development.
dc.typeArtículos de revistas


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