dc.creatorQueiroz, Mary L S
dc.creatorValadares, Marize C
dc.creatorTorello, Cristiane O
dc.creatorRamos, Aline L
dc.creatorOliveira, Alaíde B
dc.creatorRocha, Fabíola D
dc.creatorArruda, Vanessa A
dc.creatorAccorci, Walter R
dc.date2008-May
dc.date2015-11-27T13:12:36Z
dc.date2015-11-27T13:12:36Z
dc.date.accessioned2018-03-29T01:06:26Z
dc.date.available2018-03-29T01:06:26Z
dc.identifierJournal Of Ethnopharmacology. v. 117, n. 2, p. 228-35, 2008-May.
dc.identifier0378-8741
dc.identifier10.1016/j.jep.2008.01.034
dc.identifierhttp://www.ncbi.nlm.nih.gov/pubmed/18343063
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/197711
dc.identifier18343063
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1297944
dc.descriptionThe effects of Tabebuia avellanedae (TACE), traditionally prescribed in the treatment of cancer, and the naphtoquinone beta-lapachone (beta-lap) on the growth and differentiation of granulocyte and macrophage progenitor cells (CFU-GM) were studied in Ehrlich ascites tumour-bearing mice. Myelosuppression concomitant with increases in spleen CFU-GM and in serum colony-stimulating activity (CSA) were observed in these animals. Treatment with TACE (30-500 mg/kg) and beta-lap (1-5mg/kg) reversed these effects in a dose-dependent manner. The optimal biologically active doses of 120 mg/kg TACE and 1mg/kg beta-lap prolonged life span of tumour-bearing mice, both producing the same rate of extension in the duration of survival. Toxic manifestations were produced by the higher doses of beta-lap in normal and tumour-bearing mice. In spite of similarities between treatments, TACE concentrations used to treat the animals presented no traces of beta-lap, as measured by TLC and HPLC analyses. Our findings suggest that the antitumour effect of TACE and beta-lap, acting synergistically with other factors, such as specific cytokines, may result from enhanced macrophage activation against tumour cells. In addition, it is clear from our results that hematopoietic disorders produced by tumours are an important pathological condition that must be considered in drug development.
dc.description117
dc.description228-35
dc.languageeng
dc.relationJournal Of Ethnopharmacology
dc.relationJ Ethnopharmacol
dc.rightsfechado
dc.rights
dc.sourcePubMed
dc.subjectAnimals
dc.subjectAntineoplastic Agents, Phytogenic
dc.subjectBone Marrow Cells
dc.subjectCarcinoma, Ehrlich Tumor
dc.subjectChromatography, High Pressure Liquid
dc.subjectChromatography, Thin Layer
dc.subjectColony-stimulating Factors
dc.subjectGranulocyte-macrophage Colony-stimulating Factor
dc.subjectHematopoiesis
dc.subjectMale
dc.subjectMice
dc.subjectMice, Inbred Balb C
dc.subjectMyelopoiesis
dc.subjectNaphthoquinones
dc.subjectNeoplasms, Experimental
dc.subjectPlant Bark
dc.subjectPlant Extracts
dc.subjectSpleen
dc.subjectStem Cells
dc.subjectSurvival Analysis
dc.subjectTabebuia
dc.titleComparative Studies Of The Effects Of Tabebuia Avellanedae Bark Extract And Beta-lapachone On The Hematopoietic Response Of Tumour-bearing Mice.
dc.typeArtículos de revistas


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