Mice Lacking The Extracellular Matrix Protein Magp1 Display Delayed Thrombotic Occlusion Following Vessel Injury.

dc.creatorWerneck, Claudio C
dc.creatorVicente, Cristina P
dc.creatorWeinberg, Justin S
dc.creatorShifren, Adrian
dc.creatorPierce, Richard A
dc.creatorBroekelmann, Thomas J
dc.creatorTollefsen, Douglas M
dc.creatorMecham, Robert P
dc.date2008-Apr
dc.date2015-11-27T13:12:31Z
dc.date2015-11-27T13:12:31Z
dc.date.accessioned2018-03-29T01:06:20Z
dc.date.available2018-03-29T01:06:20Z
dc.identifierBlood. v. 111, n. 8, p. 4137-44, 2008-Apr.
dc.identifier0006-4971
dc.identifier10.1182/blood-2007-07-101733
dc.identifierhttp://www.ncbi.nlm.nih.gov/pubmed/18281502
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/197682
dc.identifier18281502
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1297915
dc.descriptionMice lacking the extracellular matrix protein microfibril-associated glycoprotein-1 (MAGP1) display delayed thrombotic occlusion of the carotid artery following injury as well as prolonged bleeding from a tail vein incision. Normal occlusion times were restored when recombinant MAGP1 was infused into deficient animals prior to vessel wounding. Blood coagulation was normal in these animals as assessed by activated partial thromboplastin time and prothrombin time. Platelet number was lower in MAGP1-deficient mice, but the platelets showed normal aggregation properties in response to various agonists. MAGP1 was not found in normal platelets or in the plasma of wild-type mice. In ligand blot assays, MAGP1 bound to fibronectin, fibrinogen, and von Willebrand factor, but von Willebrand factor was the only protein of the 3 that bound to MAGP1 in surface plasmon resonance studies. These findings show that MAGP1, a component of microfibrils and vascular elastic fibers, plays a role in hemostasis and thrombosis.
dc.description111
dc.description4137-44
dc.languageeng
dc.relationBlood
dc.relationBlood
dc.rightsfechado
dc.rights
dc.sourcePubMed
dc.subjectAnimals
dc.subjectBleeding Time
dc.subjectBlood Coagulation
dc.subjectBlood Platelets
dc.subjectBlood Pressure
dc.subjectCarotid Arteries
dc.subjectCattle
dc.subjectContractile Proteins
dc.subjectExtracellular Matrix Proteins
dc.subjectFibrinogen
dc.subjectFibronectins
dc.subjectHumans
dc.subjectImmunohistochemistry
dc.subjectInjections
dc.subjectMice
dc.subjectMice, Inbred C57bl
dc.subjectPlatelet Function Tests
dc.subjectProtein Binding
dc.subjectRecombinant Proteins
dc.subjectSurface Plasmon Resonance
dc.subjectThrombosis
dc.subjectVon Willebrand Factor
dc.titleMice Lacking The Extracellular Matrix Protein Magp1 Display Delayed Thrombotic Occlusion Following Vessel Injury.
dc.typeArtículos de revistas


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