Nonproliferative Epithelial Alteration And Expression Of Estrogen Receptor And Ki67 In The Contralateral Breast Of Women Treated With Tamoxifen For Breast Cancer.

dc.creatorde Souza Sales, José Fernando
dc.creatorCabello, César
dc.creatorAlvarenga, Marcelo
dc.creatorTorresan, Renato Zocchio
dc.creatorDuarte, Giuliano Mendes
dc.date2007-Apr
dc.date2015-11-27T13:10:40Z
dc.date2015-11-27T13:10:40Z
dc.date.accessioned2018-03-29T01:05:51Z
dc.date.available2018-03-29T01:05:51Z
dc.identifierBreast (edinburgh, Scotland). v. 16, n. 2, p. 197-203, 2007-Apr.
dc.identifier0960-9776
dc.identifier10.1016/j.breast.2006.10.005
dc.identifierhttp://www.ncbi.nlm.nih.gov/pubmed/17178225
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/197558
dc.identifier17178225
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1297791
dc.descriptionThe aim of study was to evaluate the frequency of nonproliferative epithelial alteration and expression of Ki67 and estrogen receptors (ER) in patients using tamoxifen. Forty-four women were selected who had been taking 20mg of tamoxifen daily for at least 12 months for adjuvant treatment of breast cancer. The women underwent core biopsy in the contralateral breast into an area of highest fibroglandular mammographic density. Fragments were analyzed by immunohistochemistry for monoclonal antibody Ki67 and ER, and histopathologic analysis. It was verified that 82% of the patients presented nonproliferative epithelial alteration, 70% were ER-negative, and all had low Ki67 expression. There was no association between duration of tamoxifen therapy, patient age, mammographic density, and presence of nonproliferative alteration (P>0.05). In conclusion, tamoxifen for more than a year showed a high frequency of nonproliferative epithelial alteration and low expression of Ki67 and ER in the normal breast tissue, consistent with low cell proliferation.
dc.description16
dc.description197-203
dc.languageeng
dc.relationBreast (edinburgh, Scotland)
dc.relationBreast
dc.rightsfechado
dc.rights
dc.sourcePubMed
dc.subjectAdult
dc.subjectAged
dc.subjectAged, 80 And Over
dc.subjectBiopsy, Needle
dc.subjectBreast Neoplasms
dc.subjectChemotherapy, Adjuvant
dc.subjectEpithelium
dc.subjectFemale
dc.subjectHumans
dc.subjectImmunohistochemistry
dc.subjectKi-67 Antigen
dc.subjectMiddle Aged
dc.subjectReceptors, Estrogen
dc.subjectSelective Estrogen Receptor Modulators
dc.subjectTamoxifen
dc.titleNonproliferative Epithelial Alteration And Expression Of Estrogen Receptor And Ki67 In The Contralateral Breast Of Women Treated With Tamoxifen For Breast Cancer.
dc.typeArtículos de revistas


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