Artículos de revistas
Vernonia Polyanthes As A New Source Of Antiulcer Drugs.
Registro en:
Fitoterapia. v. 78, n. 7-8, p. 545-51, 2007-Dec.
0367-326X
10.1016/j.fitote.2007.07.003
17904766
Autor
Barbastefano, Victor
Cola, Maira
Luiz-Ferreira, Anderson
Farias-Silva, Elisângela
Hiruma-Lima, Clélia A
Rinaldo, Daniel
Vilegas, Wagner
Souza-Brito, Alba R M
Institución
Resumen
Methanolic (VPME) and chloroformic (VPCL) extracts, obtained from the aerial parts of Vernonia polyanthes, were investigated for its antiulcerogenic properties. Administration of VPME (250 mg/kg) and VPCL (50 mg/kg) significantly inhibited the gastric mucosa damage (64% and 90%, respectively) caused by absolute ethanol (p.o.). Otherwise, in NSAID-induced gastric damage, their gastroprotective effects have decreased. Since the VPCL extract resulted to be more effective than the VPME we focused our efforts over VPCL action mechanism of action. 78 545-51