Artículos de revistas
High-performance Liquid Chromatographic Separation Of Rolipram, Bupivacaine And Omeprazole Using A Tartardiamide-based Stationary Phase Influence Of Flow Rate And Temperature On The Enantioseparation.
Registro en:
Journal Of Chromatography. A. v. 1162, n. 1, p. 97-102, 2007-Aug.
0021-9673
10.1016/j.chroma.2007.07.008
17645885
Autor
da Silva Junior, Ivanildo José
Sartor, João Paulo
Rosa, Paulo César Pires
de Veredas, Vinícius
Barreto Júnior, Amaro Gomes
Santana, Cesar Costapinto
Institución
Resumen
Chromatographic separation of the chiral drugs rolipram, bupivacaine and omeprazole on a tartardiamide-based stationary phase commercially named Kromasil CHI-TBB is shown in this work. The effect of temperature on the chromatographic separation of the chiral drugs using the Kromasil CHI-TBB stationary phase was determined quantitatively so as to contribute toward the design for the racemic mixtures of the named compound by using chiral columns. A decrease in the retention and selectivity factors was observed, when the column temperature increased. Van't Hoff plots provided the thermodynamic data. The variation of the thermodynamic parameters enthalpy and entropy are clearly negative meaning that the separation is enthalpy controlled. 1162 97-102