Artículos de revistas
The Scn2a Gene Is Not A Likely Candidate For Familial Mesial Temporal Lobe Epilepsy.
Registro en:
Epilepsy Research. v. 71, n. 2-3, p. 233-6, 2006-Oct.
0920-1211
10.1016/j.eplepsyres.2006.06.016
16914293
Autor
Maurer-Morelli, Cláudia Vianna
Secolin, Rodrigo
Marchesini, Rafael Breglio
Santos, Neide Ferreira
Kobayashi, Eliane
Cendes, Fernando
Lopes-Cendes, Iscia
Institución
Resumen
A transgenic mouse model carrying a mutation in the Scn2a gene showed chronic focal seizures associated with extensive cell loss and gliosis in the hippocampus, a similar phenotype found in familial mesial temporal lobe epilepsy (FMTLE). Our objective was to test whether the human homolog of the Scn2a gene is responsible for hippocampal abnormalities in FMTLE by linkage analysis. We conclusively ruled out the SCN2A gene as candidate in FMTLE. 71 233-6