Clinicopathologic And Immunohistochemical Study Of Intraoral Mucoepidermoid Carcinoma.

dc.creatorLopes, Márcio Ajudarte
dc.creatorda Cruz Perez, Danyel Elias
dc.creatorde Abreu Alves, Fábio
dc.creatorde Almeida, Oslei Paes
dc.creatorKowalski, Luiz Paulo
dc.date2006-Apr
dc.date2015-11-27T13:05:17Z
dc.date2015-11-27T13:05:17Z
dc.date.accessioned2018-03-29T01:02:32Z
dc.date.available2018-03-29T01:02:32Z
dc.identifierOtolaryngology--head And Neck Surgery : Official Journal Of American Academy Of Otolaryngology-head And Neck Surgery. v. 134, n. 4, p. 622-6, 2006-Apr.
dc.identifier0194-5998
dc.identifier10.1016/j.otohns.2005.12.012
dc.identifierhttp://www.ncbi.nlm.nih.gov/pubmed/16564385
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/196697
dc.identifier16564385
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1296930
dc.descriptionThe purpose of this study is to assess the clinicopathologic and immunohistochemical features of intraoral mucoepidermoid carcinomas and its relationship with the prognosis. From 1953 to 1993, 27 patients with intraoral mucoepidermoid carcinomas surgically treated were selected for this study. Clinical data were obtained from the medical records, the microscopic slides were reviewed, the tumors were graded, and immunohistochemical analysis for p53, PCNA, cerbB-2, and CEA were carried out. The tumors were more frequent in patients between 40 and 60 years of age (40.7%), without gender predilection. Hard palate was the most common site with 13 cases (48%). T2 was the more frequent stage (48%) and 2 patients (7.4%) were staged as N+. Most tumors (48%) were classified as low grade of malignancy. The expression of PCNA was associated to high-grade tumors (P = .00610) and c-erbB-2 to low grade tumors (P = .03958). No recurrence was noted in most of the cases (22 cases, 81.5%). Three cases (11.1%), however, showed local recurrence and 2 patients (7.4%) died because of the disease. The analysis of the overall survival rate showed that male patients (P = .04249), stage N (P = .05948), high grade of malignancy (P = .0009), strong expression of PCNA (P = .09128), and weak expression of c-erbB-2 (P = .03334) had the lowest survival rates. Our results showed that patients with intraoral mucoepidermoid carcinoma had a reduced survival expectation if they were of the male gender, with regional metastasis, high grade of malignancy, strong expression of PCNA and weak expression of c-erbB-2. C-4.
dc.description134
dc.description622-6
dc.languageeng
dc.relationOtolaryngology--head And Neck Surgery : Official Journal Of American Academy Of Otolaryngology-head And Neck Surgery
dc.relationOtolaryngol Head Neck Surg
dc.rightsfechado
dc.rights
dc.sourcePubMed
dc.subjectAdult
dc.subjectAntibodies, Neoplasm
dc.subjectCarcinoembryonic Antigen
dc.subjectCarcinoma, Mucoepidermoid
dc.subjectDisease Progression
dc.subjectFemale
dc.subjectHumans
dc.subjectImmunohistochemistry
dc.subjectMale
dc.subjectMiddle Aged
dc.subjectMouth Neoplasms
dc.subjectNeoplasm Staging
dc.subjectProliferating Cell Nuclear Antigen
dc.subjectReceptor, Erbb-2
dc.subjectRetrospective Studies
dc.subjectSurvival Rate
dc.subjectTumor Markers, Biological
dc.subjectTumor Suppressor Protein P53
dc.titleClinicopathologic And Immunohistochemical Study Of Intraoral Mucoepidermoid Carcinoma.
dc.typeArtículos de revistas


Este ítem pertenece a la siguiente institución