Artículos de revistas
Cytotoxic Activity Of (s)-goniothalamin And Analogues Against Human Cancer Cells.
Bioorganic & Medicinal Chemistry. v. 14, n. 3, p. 622-31, 2006-Feb.
Fátima, Angelo de
Kohn, Luciana K
Carvalho, João Ernesto de
Pilli, Ronaldo A
(R)- and (S)-Goniothalamin (1) and analogues 2-9 were efficiently prepared in high overall yield and enantiomeric purity, and their cytotoxic activities were evaluated against eight human cancer cell lines. A structure-activity relationship study (SAR) allowed us to establish the relevant structural features for the cytotoxic activity of goniothalamin analogues. In addition, we have identified non-natural form of goniothalamin (S)-1 and analogue 5 as the highest and more selective cytotoxic compounds against kidney cancer cell growth (786-0) with IC50 = 4 and 5 nM, respectively, and compound 8 (IC50 = 4 nM) as the more potent against breast cancer cells with resistance phenotype for adryamycin (NCI.ADR).14622-31