Artículos de revistas
(r)-goniothalamin: Total Syntheses And Cytotoxic Activity Against Cancer Cell Lines.
Registro en:
Bioorganic & Medicinal Chemistry. v. 13, n. 8, p. 2927-33, 2005-Apr.
0968-0896
10.1016/j.bmc.2005.02.007
15781402
Autor
de Fátima, Angelo
Kohn, Luciana Konecny
Antônio, Márcia Aparecida
de Carvalho, João Ernesto
Pilli, Ronaldo Aloise
Institución
Resumen
The total syntheses of (R)-goniothalamin (1), a styryl lactone isolated from several Goniothalamus species, via catalytic asymmetric allylation of alpha-benzyloxyacetaldehyde (2), followed by ring-closing metathesis and Wittig olefination and via catalytic asymmetric allylation of trans-cinnamaldehyde (12), followed by ring-closing metathesis are reported. The antiproliferative activities of (R)-1 and its Z-isomer 10 as well as of the synthetic dihydropyranone intermediates 7 and 8 against eight different cancer cell lines are also described. 13 2927-33