Gravimetric Method For The Determination Of Diclofenac In Pharmaceutical Preparations.

dc.creatorTubino, Matthieu
dc.creatorDe Souza, Rafael L
dc.date
dc.date2015-11-27T13:02:43Z
dc.date2015-11-27T13:02:43Z
dc.date.accessioned2018-03-29T01:01:59Z
dc.date.available2018-03-29T01:01:59Z
dc.identifierJournal Of Aoac International. v. 88, n. 6, p. 1684-7
dc.identifier1060-3271
dc.identifier
dc.identifierhttp://www.ncbi.nlm.nih.gov/pubmed/16526451
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/196552
dc.identifier16526451
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1296785
dc.descriptionA gravimetric method for the determination of diclofenac in pharmaceutical preparations was developed. Diclofenac is precipitated from aqueous solution with copper(II) acetate in pH 5.3 (acetic acid/acetate buffer). Sample aliquots had approximately the same quantity of the drug content in tablets (50 mg) or in ampules (75 mg). The observed standard deviation was about +/- 2 mg; therefore, the relative standard deviation (RSD) was approximately 4% for tablet and 3% for ampule preparations. The results were compared with those obtained with the liquid chromatography method recommended in the United States Pharmacopoeia using the statistical Student's t-test. Complete agreement was observed. It is possible to obtain more precise results using higher aliquots, for example 200 mg, in which case the RSD falls to 1%. This gravimetric method, contrary to what is expected for this kind of procedure, is relatively fast and simple to perform. The main advantage is the absolute character of the gravimetric analysis.
dc.description88
dc.description1684-7
dc.languageeng
dc.relationJournal Of Aoac International
dc.relationJ AOAC Int
dc.rightsfechado
dc.rights
dc.sourcePubMed
dc.subjectCentrifugation
dc.subjectChemistry Techniques, Analytical
dc.subjectChemistry, Pharmaceutical
dc.subjectChromatography, Liquid
dc.subjectCopper
dc.subjectDiclofenac
dc.subjectFiltration
dc.subjectGravitation
dc.subjectHydrogen-ion Concentration
dc.subjectModels, Chemical
dc.subjectModels, Statistical
dc.subjectPharmaceutical Preparations
dc.subjectPotassium
dc.subjectReproducibility Of Results
dc.subjectSodium
dc.subjectTablets
dc.titleGravimetric Method For The Determination Of Diclofenac In Pharmaceutical Preparations.
dc.typeArtículos de revistas


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