Tissue Remodeling In Guinea Pig Lateral Prostate At Different Ages After Estradiol Treatment.

dc.creatorScarano, Wellerson Rodrigo
dc.creatorCordeiro, Renato Simões
dc.creatorGóes, Rejane Maira
dc.creatorCarvalho, Hernandes F
dc.creatorTaboga, Sebastião Roberto
dc.date2005-Sep
dc.date2015-11-27T13:02:20Z
dc.date2015-11-27T13:02:20Z
dc.date.accessioned2018-03-29T01:01:15Z
dc.date.available2018-03-29T01:01:15Z
dc.identifierCell Biology International. v. 29, n. 9, p. 778-84, 2005-Sep.
dc.identifier1065-6995
dc.identifier10.1016/j.cellbi.2005.05.003
dc.identifierhttp://www.ncbi.nlm.nih.gov/pubmed/16095928
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/196368
dc.identifier16095928
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1296601
dc.descriptionEstrogen seems to have an essential role in the fibromuscular growth characteristic of benign prostatic hyperplasia (BPH). This paper describes the effects of chronic estradiol treatment on Guinea pig prostatic stroma at different ages. Tissues from experimental animals were studied by histological and histochemical procedures, morphometric-stereological analysis and transmission electron microscopy (TEM). Marked fibromuscular hypertrophy was observed after estradiol treatment in animals of pre-pubertal and adult ages. Increases in the density and thickness of the collagen and elastic fibers were observed by histochemistry. TEM revealed wide distributions of collagen fibrils and large elastic fibers adjacent to the epithelial basal lamina and between the stromal cells, establishing contacts between them. These results indicate that the Guinea pig prostate simulates the stromal modifications observed in BPH in some aged animals after estrogen treatment at different ages, making it a good model for this disease.
dc.description29
dc.description778-84
dc.languageeng
dc.relationCell Biology International
dc.relationCell Biol. Int.
dc.rightsfechado
dc.rights
dc.sourcePubMed
dc.subjectAge Factors
dc.subjectAnimals
dc.subjectCollagen
dc.subjectDisease Models, Animal
dc.subjectEpithelial Cells
dc.subjectEstradiol
dc.subjectGuinea Pigs
dc.subjectMale
dc.subjectMicroscopy, Electron, Transmission
dc.subjectMyocytes, Smooth Muscle
dc.subjectProstate
dc.subjectProstatic Hyperplasia
dc.subjectStromal Cells
dc.titleTissue Remodeling In Guinea Pig Lateral Prostate At Different Ages After Estradiol Treatment.
dc.typeArtículos de revistas


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