Fast Screening Of Low Molecular Weight Compounds By Thin-layer Chromatography And On-spot" Maldi-tof Mass Spectrometry."

dc.creatorSantos, Leonardo S
dc.creatorHaddad, Renato
dc.creatorHöehr, Nelci F
dc.creatorPilli, Ronaldo A
dc.creatorEberlin, Marcos N
dc.date2004-Apr
dc.date2015-11-27T12:58:50Z
dc.date2015-11-27T12:58:50Z
dc.date.accessioned2018-03-29T01:00:30Z
dc.date.available2018-03-29T01:00:30Z
dc.identifierAnalytical Chemistry. v. 76, n. 7, p. 2144-7, 2004-Apr.
dc.identifier0003-2700
dc.identifier10.1021/ac035387d
dc.identifierhttp://www.ncbi.nlm.nih.gov/pubmed/15053682
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/196180
dc.identifier15053682
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1296413
dc.descriptionFast screening of low-MW compounds is performed by thin-layer chromatography (TLC) followed by direct on-spot matrix-assisted laser desorption/ionization time-of-flight mass spectrometry identification with nearly matrix-free mass spectra using an UV-absorbing ionic liquid matrix. Owing to minimal background ions from the proton donor triethylamine/alpha-cyano-4-hydroxycinnamic acid ionic liquid matrix, three arborescidine alkaloids, the anesthesics levobupivacaine and mepivacaine, and the antibiotic tetracycline were readily characterized most frequently by the MS detection of their protonated molecules. The technique is fast and sensitive, requires little sample preparation and manipulation, and is therefore suitable for fast screening with TLC separation and MS identification of low-MW compounds, with potential applications in areas such as phytochemistry, synthetic chemistry, and product manufacturing quality monitoring.
dc.description76
dc.description2144-7
dc.languageeng
dc.relationAnalytical Chemistry
dc.relationAnal. Chem.
dc.rightsfechado
dc.rights
dc.sourcePubMed
dc.subjectAlkaloids
dc.subjectAnesthetics
dc.subjectAnti-bacterial Agents
dc.subjectBupivacaine
dc.subjectChromatography, Thin Layer
dc.subjectIndole Alkaloids
dc.subjectIndoles
dc.subjectMepivacaine
dc.subjectMolecular Weight
dc.subjectProtons
dc.subjectSpectrometry, Mass, Matrix-assisted Laser Desorption-ionization
dc.subjectTetracycline
dc.subjectTime Factors
dc.titleFast Screening Of Low Molecular Weight Compounds By Thin-layer Chromatography And On-spot" Maldi-tof Mass Spectrometry."
dc.typeArtículos de revistas


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