Myelopoietic Response In Mice Exposed To Acute Cold/restraint Stress: Modulation By Chlorella Vulgaris Prophylactic Treatment.

dc.creatorde Souza Queiroz, Julia
dc.creatorMalacrida, Solange A
dc.creatorJusto, Giselle Z
dc.creatorQueiroz, Mary L S
dc.date2004-Aug
dc.date2015-11-27T12:58:33Z
dc.date2015-11-27T12:58:33Z
dc.date.accessioned2018-03-29T00:59:50Z
dc.date.available2018-03-29T00:59:50Z
dc.identifierImmunopharmacology And Immunotoxicology. v. 26, n. 3, p. 455-67, 2004-Aug.
dc.identifier0892-3973
dc.identifier
dc.identifierhttp://www.ncbi.nlm.nih.gov/pubmed/15518178
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/196010
dc.identifier15518178
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1296243
dc.descriptionIn this study, hematopoietic cells from mice pretreated with CVE and exposed to acute cold/restraint stress were stimulated in the presence of growth factors to form colonies, thus providing accurate information about the modulation of the green algae of the stress-induced changes in the hematopoietic response. Our results demonstrated that exposure to acute stress affected hematopoiesis. Mice exposed for a 2.5-hour time period of cold and restraint presented diminished clonal capacity for CFU-GM content per femur, which was decreased by as much as 50% compared with that in control mice, in spite of the significant increase in serum colony-stimulating activity (CSA). Treatment with 50 mg/kg CVE for 5 days, previously to the stress regimen, attenuates the effects of the stress, since comparable levels of myeloid progenitors were found in the bone marrow of both CVE/stress and control mice. Moreover, the sera from stressed mice pretreated with CVE further increased the CFU-GM formation. On the contrary, the spleen seemed to be less sensitive to acute stress in our experimental conditions. These findings are in line with our previous reports showing that the stress-induced reduction in bone marrow CFU-GM of rats exposed to electric shocks is mediated by activation of the HPA axis and by secretion of opioid agonists. No changes were observed in bone marrow, spleen and thymus total cell counts, and in relative organ weights. However, a 50% reduction in the body weight loss produced by the stress was observed in mice given the extract.
dc.description26
dc.description455-67
dc.languageeng
dc.relationImmunopharmacology And Immunotoxicology
dc.relationImmunopharmacol Immunotoxicol
dc.rightsfechado
dc.rights
dc.sourcePubMed
dc.subjectAnimals
dc.subjectBone Marrow Cells
dc.subjectChlorella Vulgaris
dc.subjectCold Temperature
dc.subjectColony-forming Units Assay
dc.subjectColony-stimulating Factors
dc.subjectGranulocyte-macrophage Colony-stimulating Factor
dc.subjectMale
dc.subjectMice
dc.subjectMyelopoiesis
dc.subjectPlant Extracts
dc.subjectRecombinant Proteins
dc.subjectRestraint, Physical
dc.subjectStress, Physiological
dc.subjectWeight Loss
dc.titleMyelopoietic Response In Mice Exposed To Acute Cold/restraint Stress: Modulation By Chlorella Vulgaris Prophylactic Treatment.
dc.typeArtículos de revistas


Este ítem pertenece a la siguiente institución