Artículos de revistas
Protective Effect Of Bovine Milk Whey Protein Concentrate On The Ulcerative Lesions Caused By Subcutaneous Administration Of Indomethacin.
Journal Of Medicinal Food. v. 7, n. 3, p. 309-14, 2004.
Rosaneli, C F
Bighetti, A E
Antônio, M A
Carvalho, J E
Sgarbieri, V C
The protective effect of a whey protein concentrate (WPC) was studied in three models of stomach ulcerative lesions induction: subcutaneous injection of indomethacin, and stress induced by either intraperitoneal injection of reserpine, or immobilization and holding in the cold (4 degrees C, 2 hours). Adult Wistar rats (300-400 g) were used for acute (single-dose), repetitive, or subchronic (10 days) administration of WPC prior to treatment with the ulcerogenic factors. The best protection was achieved in the indomethacin model for repetitive and subchronic experiments, reaching 50.1% and 44%, respectively, inhibition of the ulcerative lesions, which was significant at 1% probability (P <.01). For the immobilization and cold model, maximum inhibition by WPC was 22.1%, and that for the reserpine model was 23.8%. In both models the inhibition was not significant (P >.05) compared with saline (negative control).7309-14