Effect Of Naproxen On Tail Fin Regeneration In Teleost.

dc.creatorBöckelmann, P K
dc.creatorBechara, I J
dc.date2004-Jan
dc.date2015-11-27T12:58:23Z
dc.date2015-11-27T12:58:23Z
dc.date.accessioned2018-03-29T00:59:29Z
dc.date.available2018-03-29T00:59:29Z
dc.identifierJournal Of Submicroscopic Cytology And Pathology. v. 36, n. 1, p. 55-64, 2004-Jan.
dc.identifier1122-9497
dc.identifier
dc.identifierhttp://www.ncbi.nlm.nih.gov/pubmed/15311675
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/195918
dc.identifier15311675
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1296151
dc.descriptionIn the present investigation we studied the effect of naproxen, a non-steroidal anti-inflammatory drug used for the treatment of rheumatic disease, on the synthesis of the lepidotrichial matrix of the tail fin of the teleost fish Cyprinus carpio (carp) during the regeneration process. The lepidotrichial synthesis was observed by standard and polarized light microscopy and by transmission electron microscopy. In general, naproxen at the dose used in the present study did not affect the organization of the extracellular matrix components and the mineralization of the fundamental substance of the lepidotrichia during the process of tail fin regeneration. Since the effect of naproxen, as well as of other non-steroidal anti-inflammatory drugs, depends on the dose used, the route of administration and the metabolism of the animal in which the drug is being tested, higher doses of the drug may perhaps delay or even fully inhibit this process, possibly also provoke disorganization of the lepidotrichial matrix.
dc.description36
dc.description55-64
dc.languageeng
dc.relationJournal Of Submicroscopic Cytology And Pathology
dc.relationJ. Submicrosc. Cytol. Pathol.
dc.rightsfechado
dc.rights
dc.sourcePubMed
dc.subjectAnimals
dc.subjectAnti-inflammatory Agents, Non-steroidal
dc.subjectCarps
dc.subjectDose-response Relationship, Drug
dc.subjectExtracellular Matrix
dc.subjectMicroscopy, Electron, Transmission
dc.subjectMicroscopy, Polarization
dc.subjectNaproxen
dc.subjectRegeneration
dc.subjectTail
dc.titleEffect Of Naproxen On Tail Fin Regeneration In Teleost.
dc.typeArtículos de revistas


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