Artículos de revistas
Glucocorticoid Receptor And Beta-adrenoceptor Expression In Epididymal Adipose Tissue From Stressed Rats.
Registro en:
Annals Of The New York Academy Of Sciences. v. 1018, p. 328-32, 2004-Jun.
0077-8923
10.1196/annals.1296.040
15240386
Autor
Farias-Silva, Elisangela
dos Santos, Iraídes Nunes
Corezola do Amaral, Maria Esméria
Grassi-Kassisse, Dora Maria
Spadari-Bratfisch, Regina Celia
Institución
Resumen
Adipocytes isolated from epididymal adipose tissue of foot-shock stressed rats are supersensitive to isoprenaline and subsensitive to norepinephrine. These alterations are probably mediated by a stress-induced increase in plasma corticosterone levels. We investigated whether foot-shock stress modifies the expression of glucocorticoid receptors (GRs) and beta-adrenergic protein receptors (beta-ARs) in epididymal adipose tissue from rats submitted to one daily foot-shock session on three consecutive days. This stress protocol caused decreases in GR, beta(1)-AR, and beta(3)-AR protein levels, but caused an increase in beta(2)-AR. These results confirm and support previous functional studies. The alterations in protein expression may be modulated by the high corticosterone levels that downregulate the glucocorticoid receptor. 1018 328-32