Aspirin Inhibits Serine Phosphorylation Of Irs-1 In Muscle And Adipose Tissue Of Septic Rats.

dc.creatorBarreiro, Guilherme C
dc.creatorPrattali, Raphael R
dc.creatorCaliseo, Caio T
dc.creatorFugiwara, Felipe Y
dc.creatorUeno, Mirian
dc.creatorPrada, Patrícia O
dc.creatorVelloso, Lício A
dc.creatorSaad, Mario J A
dc.creatorCarvalheira, José B C
dc.date2004-Jul
dc.date2015-11-27T12:58:17Z
dc.date2015-11-27T12:58:17Z
dc.date.accessioned2018-03-29T00:59:15Z
dc.date.available2018-03-29T00:59:15Z
dc.identifierBiochemical And Biophysical Research Communications. v. 320, n. 3, p. 992-7, 2004-Jul.
dc.identifier0006-291X
dc.identifier10.1016/j.bbrc.2004.06.048
dc.identifierhttp://www.ncbi.nlm.nih.gov/pubmed/15240146
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/195856
dc.identifier15240146
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1296089
dc.descriptionWhole body insulin resistance has been demonstrated in septic patients and in infected animals. In this study, we demonstrate that sepsis induces insulin resistance and that pretreatment with aspirin inhibits sepsis-induced insulin resistance. Sepsis was observed to lead to serine phosphorylation of IRS-1, a phenomenon which was reversed by aspirin in muscle and WAT, in parallel with a reduction in JNK activity. In addition, our data show an impairment of insulin activation of IR and IRS-1 tyrosine phosphorylation in septic rats and, consistent with the reduction of IRS-1 serine phosphorylation observed in septic animals pretreated with aspirin, there was an increase in IRS-1 protein levels and tyrosine phosphorylation in muscle and WAT. Overall, these results provide important new insights into the mechanism of sepsis-induced insulin resistance.
dc.description320
dc.description992-7
dc.languageeng
dc.relationBiochemical And Biophysical Research Communications
dc.relationBiochem. Biophys. Res. Commun.
dc.rightsfechado
dc.rights
dc.sourcePubMed
dc.subjectAdipose Tissue
dc.subjectAnimals
dc.subjectAspirin
dc.subjectInsulin Receptor Substrate Proteins
dc.subjectInsulin Resistance
dc.subjectMale
dc.subjectMuscle, Skeletal
dc.subjectPhosphoproteins
dc.subjectPhosphorylation
dc.subjectRats
dc.subjectRats, Wistar
dc.subjectSepsis
dc.subjectSerine
dc.titleAspirin Inhibits Serine Phosphorylation Of Irs-1 In Muscle And Adipose Tissue Of Septic Rats.
dc.typeArtículos de revistas


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