Human Leukocyte Formin: A Novel Protein Expressed In Lymphoid Malignancies And Associated With Akt.

dc.creatorFavaro, Patricia M Bergamo
dc.creatorde Souza Medina, Samuel
dc.creatorTraina, Fabíola
dc.creatorBassères, Daniela Sanchez
dc.creatorCosta, Fernando Ferreira
dc.creatorSaad, Sara Teresinha Olalla
dc.date2003-Nov
dc.date2015-11-27T12:52:32Z
dc.date2015-11-27T12:52:32Z
dc.date.accessioned2018-03-29T00:58:13Z
dc.date.available2018-03-29T00:58:13Z
dc.identifierBiochemical And Biophysical Research Communications. v. 311, n. 2, p. 365-71, 2003-Nov.
dc.identifier0006-291X
dc.identifier
dc.identifierhttp://www.ncbi.nlm.nih.gov/pubmed/14592423
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/195583
dc.identifier14592423
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1295816
dc.descriptionThe very large family of Formin proteins is involved in processes such as morphogenesis, embryonic differentiation, cell polarity, and cytokinesis. A novel human gene from the Formin family, denominated human leukocyte formin gene, was cloned. The cDNA of the gene was determined to be 3959bp long with an open reading frame of 3302bp and computational analysis located this gene on chromosome 17, suggesting that it is composed of 27 exons. Northern blot analysis revealed a restricted expression of mRNA in the thymus, spleen, and peripheral blood leukocytes in normal human tissues. Western blot analysis demonstrated that the protein encoded by this gene is overexpressed in lymphoid malignancies; cancer cell lines and peripheral blood leukocyte from chronic lymphocytic leukemia (CLL) patients. Furthermore, the human leukocyte formin protein was observed to associate with Akt, a critical survival regulator in many different cell types.
dc.description311
dc.description365-71
dc.languageeng
dc.relationBiochemical And Biophysical Research Communications
dc.relationBiochem. Biophys. Res. Commun.
dc.rightsfechado
dc.rights
dc.sourcePubMed
dc.subjectAmino Acid Sequence
dc.subjectCell Line, Tumor
dc.subjectCytoskeletal Proteins
dc.subjectGene Expression Regulation, Neoplastic
dc.subjectHl-60 Cells
dc.subjectHumans
dc.subjectJurkat Cells
dc.subjectLeukemia, Lymphocytic, Chronic, B-cell
dc.subjectLeukocytes, Mononuclear
dc.subjectMolecular Sequence Data
dc.subjectProtein-serine-threonine Kinases
dc.subjectProto-oncogene Proteins
dc.subjectProto-oncogene Proteins C-akt
dc.subjectSequence Analysis, Protein
dc.titleHuman Leukocyte Formin: A Novel Protein Expressed In Lymphoid Malignancies And Associated With Akt.
dc.typeArtículos de revistas


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