Quantification Of Hippocampal Signal Intensity In Patients With Mesial Temporal Lobe Epilepsy.

dc.creatorCoan, Ana Carolina
dc.creatorKobayashi, Eliane
dc.creatorLi, Li Min
dc.creatorCendes, Fernando
dc.date2003-Jul
dc.date2015-11-27T12:52:19Z
dc.date2015-11-27T12:52:19Z
dc.date.accessioned2018-03-29T00:57:47Z
dc.date.available2018-03-29T00:57:47Z
dc.identifierJournal Of Neuroimaging : Official Journal Of The American Society Of Neuroimaging. v. 13, n. 3, p. 228-33, 2003-Jul.
dc.identifier1051-2284
dc.identifier
dc.identifierhttp://www.ncbi.nlm.nih.gov/pubmed/12889169
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/195471
dc.identifier12889169
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1295704
dc.descriptionRefractory mesial temporal lobe epilepsy (MTLE) is frequently associated with hippocampal atrophy (HA) and an abnormal hippocampal signal (Hsig) on magnetic resonance imaging (MRI). To quantify Hsig on MRI using a simplified technique. The authors included 15 patients with refractory MTLE who underwent surgery and had preoperative MRI with hippocampal volumetry. Hsig was quantified on preoperative coronal T1-weighted and T2-weighted MRI using the NIH-Image program. Hsig was determined for the head, tail, and entire hippocampal extension. Abnormal Hsig was defined when values were above (for T2) or below (for T1) 2 standard deviations from the mean of normal control group. The lateralization of abnormal Hsig values was concordant with electroencephalograms and HA in all patients. There was a significant difference in ipsilateral T2 Hsig between patients and controls (P < .0001), but not for contralateral T2 Hsig. T1 Hsig showed bilateral abnormalities more frequently, whereas T2 Hsig could lateralize better hippocampal abnormalities. Overall, there were no differences when comparing T2 Hsig for the entire hippocampus, head, or tail only. However, there were some individual differences. T2 Hsig abnormalities involved the entire hippocampus in most patients but were restricted to the head in one patient and to the tail in another. This simplified method for the quantification of Hsig using NHI-Image is an efficient method for the identification and quantification of hippocampal abnormalities in patients with MTLE. The assessment of the entire extension of the hippocampal formation may provide important additional data, compared to T2 relaxometry maps limited to one segment of the hippocampus.
dc.description13
dc.description228-33
dc.languageeng
dc.relationJournal Of Neuroimaging : Official Journal Of The American Society Of Neuroimaging
dc.relationJ Neuroimaging
dc.rightsfechado
dc.rights
dc.sourcePubMed
dc.subjectAdult
dc.subjectAnalysis Of Variance
dc.subjectAtrophy
dc.subjectEpilepsy, Temporal Lobe
dc.subjectFemale
dc.subjectHippocampus
dc.subjectHumans
dc.subjectMagnetic Resonance Imaging
dc.subjectMale
dc.subjectMiddle Aged
dc.subjectSignal Processing, Computer-assisted
dc.titleQuantification Of Hippocampal Signal Intensity In Patients With Mesial Temporal Lobe Epilepsy.
dc.typeArtículos de revistas


Este ítem pertenece a la siguiente institución