Costimulatory Molecule Expression On Leukocytes From Mice With Experimental Autoimmune Encephalomyelitis Treated With Ifn-beta.

dc.creatorHallal, Dannie E M
dc.creatorFarias, Alessandro S
dc.creatorOliveira, Elaine C
dc.creatorDiaz-Bardales, Blanca Maria
dc.creatorBrandão, Carlos Otavio
dc.creatorProtti, Gustavo G
dc.creatorPereira, Fernanda G
dc.creatorMetze, Irene L
dc.creatorSantos, Leonilda M B
dc.date2003-Jun
dc.date2015-11-27T12:52:16Z
dc.date2015-11-27T12:52:16Z
dc.date.accessioned2018-03-29T00:57:41Z
dc.date.available2018-03-29T00:57:41Z
dc.identifierJournal Of Interferon & Cytokine Research : The Official Journal Of The International Society For Interferon And Cytokine Research. v. 23, n. 6, p. 293-8, 2003-Jun.
dc.identifier1079-9907
dc.identifier10.1089/107999003766628133
dc.identifierhttp://www.ncbi.nlm.nih.gov/pubmed/12859855
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/195447
dc.identifier12859855
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1295680
dc.descriptionInterferon-beta (IFN-beta) is of benefit in the treatment of multiple sclerosis (MS) and experimental autoimmune encephalomyelitis (EAE), but the mechanisms by which it exerts this beneficial effect remain uncertain. The present data demonstrate that IFN-beta therapy impairs the proliferative response to concanavalin A (ConA) and myelin basic protein (MBP), decreases expression of the CD80 molecule on leukocytes of treated mice, and may thereby impede the Th1 cell activation-promoting anergy in EAE. Moreover, IFN-beta therapy increases expression of the CTLA4 molecule, which induces a counterregulatory Th2 response. The reduction of CD80 expression with concomitant increase of CTLA4 expression alters the course of EAE and may be useful as a monitor in therapy with IFN-beta.
dc.description23
dc.description293-8
dc.languageeng
dc.relationJournal Of Interferon & Cytokine Research : The Official Journal Of The International Society For Interferon And Cytokine Research
dc.relationJ. Interferon Cytokine Res.
dc.rightsfechado
dc.rights
dc.sourcePubMed
dc.subjectAnimals
dc.subjectAntigens, Cd
dc.subjectAntigens, Cd80
dc.subjectAntigens, Differentiation
dc.subjectCtla-4 Antigen
dc.subjectEncephalomyelitis, Autoimmune, Experimental
dc.subjectFemale
dc.subjectInterferon-beta
dc.subjectLymphocyte Activation
dc.subjectMice
dc.subjectMultiple Sclerosis
dc.subjectT-lymphocytes
dc.titleCostimulatory Molecule Expression On Leukocytes From Mice With Experimental Autoimmune Encephalomyelitis Treated With Ifn-beta.
dc.typeArtículos de revistas


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