No Association Of The 5' Promoter Region Polymorphism Of Cyp17 Gene With Prostate Cancer Risk.

dos Santos, A; Ribeiro, M L; Mesquita, J C; Carvalho-Salles, A B; Hackel, C

Artículos de revistas

Registro en:

Prostate Cancer And Prostatic Diseases. v. 5, n. 1, p. 28-31, 2002.

1365-7852

10.1038/sj.pcan.4500550

http://www.ncbi.nlm.nih.gov/pubmed/15195127

http://repositorio.unicamp.br/jspui/handle/REPOSIP/195264

15195127

http://repositorioslatinoamericanos.uchile.cl/handle/2250/1295497

Autor

dos Santos, A

Ribeiro, M L

Mesquita, J C

Carvalho-Salles, A B

Hackel, C

Institución

Universidade Estadual de Campinas (Brasil)

Resumen

CYP17 gene encodes the enzyme cytochrome p450c17alpha, which mediates two steps in the steroid biosynthesis pathway. Steroid hormones are believed to play a key role in the etiology of prostate cancer. A polymorphic T-->C transition in the 5(') promoter region of CYP17 creates an additional Sp1-type (CCACC box) promoter site (allele A2). We have evaluated the genotypic and allelic distribution of this polymorphism among 92 prostate cancer patients in order to assess risk by comparison with a population-based series of 200 healthy individuals from Brazil. Our results provide no evidence for an association between prostate cancer risk and CYP17 T/C polymorphism.

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