Mouse Extensor Digitorum Longus And Soleus Show Distinctive Ultrastructural Changes Induced By Veratrine.

dc.creatorDa Cruz Höfling, M A
dc.creatorDal Pai Silva, M
dc.creatorSilva Freitas, E M
dc.date2002-Jul
dc.date2015-11-27T12:49:21Z
dc.date2015-11-27T12:49:21Z
dc.date.accessioned2018-03-29T00:56:39Z
dc.date.available2018-03-29T00:56:39Z
dc.identifierJournal Of Submicroscopic Cytology And Pathology. v. 34, n. 3, p. 305-13, 2002-Jul.
dc.identifier1122-9497
dc.identifier
dc.identifierhttp://www.ncbi.nlm.nih.gov/pubmed/12408364
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/195180
dc.identifier12408364
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1295413
dc.descriptionWe investigated whether veratrine (5 microl, 10 ng/kg) injected into the mouse extensor digitorum longus (EDL) (fast-twitch) and soleus (SOL) (slow-twitch) muscles provokes distinctive ultrastructural disturbances 15, 30 and 60 min later. The mitochondria in SOL were affected earlier (within 15 min) than in EDL. Swelling of the sarcoplasmic reticulum terminal cisternae was more marked in EDL than in SOL and caused distortion of sarcomeres so that fragmentation of myofilaments was more pronounced in EDL. Hypercontracted sarcomeres were seen mainly in SOL and veratrine caused infoldings of the sarcolemma only in this muscle. In both muscles, the T-tubules remained unaffected and by 60 min after veratrine most of the above alterations had reverted to normal. Pretreatment with tetrodotoxin prevented the alterations induced by veratrine. This suggests that most of the alterations resulted from the enhanced influx of Na+ into muscle fibers. These results emphasize the importance of considering the type of muscle when studying the action of myotoxic agents.
dc.description34
dc.description305-13
dc.languageeng
dc.relationJournal Of Submicroscopic Cytology And Pathology
dc.relationJ. Submicrosc. Cytol. Pathol.
dc.rightsfechado
dc.rights
dc.sourcePubMed
dc.subjectAnimals
dc.subjectDrug Antagonism
dc.subjectMale
dc.subjectMice
dc.subjectMice, Inbred Balb C
dc.subjectMitochondria
dc.subjectMuscle Fibers, Fast-twitch
dc.subjectMuscle Fibers, Slow-twitch
dc.subjectMuscle, Skeletal
dc.subjectMuscular Diseases
dc.subjectSarcomeres
dc.subjectTetrodotoxin
dc.subjectVeratrine
dc.titleMouse Extensor Digitorum Longus And Soleus Show Distinctive Ultrastructural Changes Induced By Veratrine.
dc.typeArtículos de revistas


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