Artículos de revistas
Effects Of The Green Algae Chlorella Vulgaris On The Response Of The Host Hematopoietic System To Intraperitoneal Ehrlich Ascites Tumor Transplantation In Mice.
Registro en:
Immunopharmacology And Immunotoxicology. v. 23, n. 1, p. 119-32, 2001-Feb.
0892-3973
10.1081/IPH-100102573
11322644
Autor
Justo, G Z
Silva, M R
Queiroz, M L
Institución
Resumen
Chlorella vulgaris extract (CVE) was examined for its effects on the Ehrlich ascites tumor-induced suppression in the numbers of bone marrow and spleen granulocyte-macrophage progenitor cells (CFU-GM) in mice. No effects on bone marrow and spleen CFU-GM, as compared to controls, were observed in normal mice given 50, 100 and 200 mg/kg CVE orally for 5 days. In tumor-bearing mice, myelosuppression concomitant with increased number of spleen CFU-GM were observed. The number of CFU-GM in the bone marrow was restored to control levels after the administration of CVE (50, 100 and 200 mg/kg) to tumor-bearing mice, and a slight reduction in spleen colony formation was observed in these animals. In addition, CVE significantly prolonged the survival of mice inoculated with the Ehrlich ascites tumor. These results suggest a protective antitumor effect of CVE which might be attributable, at least in part, to the stimulation of the production and, possibly, maturation of granulocytes and macrophages. 23 119-32