Delayed First Injection Of The Once-a-month Injectable Contraceptive Containing 25 Mg Medroxyprogesterone Acetate And 5 Mg Estradiol-cypionate: Effects On Cervical Mucus.

dc.creatorPetta, C A
dc.creatorHays, M
dc.creatorBrache, V
dc.creatorMassai, R
dc.creatorHua, Y
dc.creatorAlvarez-Sánchez, F
dc.creatorSalvatierra, A
dc.creatord'Arcangues, C
dc.creatorCook, L A
dc.creatorBahamondes, L
dc.date2001-Dec
dc.date2015-11-27T12:29:09Z
dc.date2015-11-27T12:29:09Z
dc.date.accessioned2018-03-29T00:55:42Z
dc.date.available2018-03-29T00:55:42Z
dc.identifierContraception. v. 64, n. 6, p. 363-8, 2001-Dec.
dc.identifier0010-7824
dc.identifier
dc.identifierhttp://www.ncbi.nlm.nih.gov/pubmed/11834235
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/194933
dc.identifier11834235
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1295166
dc.descriptionThe objectives of this study were to assess whether women who were administered the first injection of the once-a-month contraceptive containing estradiol cypionate and 25 mg depot-medroxyprogesterone acetate (MPA+E(2)C) on Day 7 of their menstrual cycle (delayed injection) exhibit the same degree of cervical mucus changes as women who receive it on Day 5 of their menstrual cycle. This was a multicenter, randomized, controlled clinical trial. A total of 158 women, aged between 18 and 38 years (inclusive), who, were willing to use MPA+E(2)C as their contraceptive method participated in the trial. Participants received a MPA+E(2)C injection on Day 5 (control group, n = 41) or Day 7 (delayed-injection group, n = 117) of their menstrual cycle. Participants who received MPA+E(2)C on Day 5 of their menstrual cycle (control group) exhibited fair or poor mucus quality and poor sperm penetration. Of those women who received MPA+E(2)C on Day 7 of their menstrual cycle (delayed-injection group), 3 (3%) showed good mucus or good sperm penetration at some time point during follow-up. It is possible to conclude that the first injection of MPA+E(2)C given on Day 7 of a menstrual cycle does not provide the same degree of inhibition of mucus quality and sperm penetration as that observed if it is administered on Day 5. However, the theoretical risk of pregnancy after receiving MPA+E(2)C on Day 7 would be expected to be low.
dc.description64
dc.description363-8
dc.languageeng
dc.relationContraception
dc.relationContraception
dc.rightsfechado
dc.rights
dc.sourcePubMed
dc.subjectAdult
dc.subjectCervix Mucus
dc.subjectContraceptive Agents, Female
dc.subjectContraceptives, Oral, Combined
dc.subjectDelayed-action Preparations
dc.subjectDrug Administration Schedule
dc.subjectEstradiol
dc.subjectFemale
dc.subjectHumans
dc.subjectInjections, Intramuscular
dc.subjectMedroxyprogesterone Acetate
dc.subjectOvary
dc.subjectSperm-ovum Interactions
dc.subjectTime Factors
dc.titleDelayed First Injection Of The Once-a-month Injectable Contraceptive Containing 25 Mg Medroxyprogesterone Acetate And 5 Mg Estradiol-cypionate: Effects On Cervical Mucus.
dc.typeArtículos de revistas


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